HDL cholesterol and protective factors in atherosclerosis

Article

关键词: HIGH-DENSITY-LIPOPROTEIN;    CORONARY-HEART-DISEASE;    APOLIPOPROTEIN-A-I;    SECONDARY PREVENTION;    SCAVENGER RECEPTOR;    SERUM PARAOXONASE;    TANGIER-DISEASE;    ARTERY-DISEASE;    LIPID EFFLUX;    RISK-FACTORS;   

DOI  :  10.1161/01.CIR.0000131512.50667.46

来源: SCIE

【 摘 要 】

A low level of high-density lipoprotein cholesterol (HDL-C) is an important risk factor for cardiovascular disease. Epidemiological and clinical studies provide evidence that HDL-C levels are linked to rates of coronary events. The cardioprotective effects of HDL-C have been attributed to its role in reverse cholesterol transport, its effects on endothelial cells, and its antioxidant activity. Although some clinical trials suggest a benefit of raising HDL-C to reduce risk, further studies are needed, and HDL-C is still not considered a primary target of therapy in the National Cholesterol Education Program guidelines. However, HDL-C should be considered as part of the patient's overall profile of established risk factors in determining treatment strategies.

【 授权许可】

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