Community-associated meticillin-resistant Staphylococcus aureus

Article

关键词: PANTON-VALENTINE LEUKOCIDIN;    CASSETTE CHROMOSOME MEC;    SOFT-TISSUE INFECTIONS;    METHICILLIN-RESISTANT;    DOUBLE-BLIND;    UNITED-STATES;    NASAL CARRIAGE;    RISK-FACTORS;    ALPHA-TOXIN;    TRIMETHOPRIM-SULFAMETHOXAZOLE;   

DOI  :  10.1016/S0140-6736(09)61999-1

来源: SCIE

【 摘 要 】

Meticillin-resistant Staphylococcus aureus (MRSA) is endemic in hospitals worldwide, and causes substantial morbidity and mortality. Health-care-associated MRSA infections arise in individuals with predisposing risk factors, such as surgery or presence of an indwelling medical device. By contrast, many community-associated MRSA (CA-MRSA) infections arise in otherwise healthy individuals who do not have such risk factors. Additionally, CA-MRSA infections are epidemic in some countries. These features suggest that CA-MRSA strains are more virulent and transmissible than are traditional hospital-associated MRSA strains. The restricted treatment options for CA-MRSA infections compound the effect of enhanced virulence and transmission. Although progress has been made towards understanding emergence of CA-MRSA, virulence, and treatment of infections, our knowledge remains incomplete. Here we review the most up-to-date knowledge and provide a perspective for the future prophylaxis or new treatments for CA-MRSA infections.

【 授权许可】

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