Caloric restriction disrupts the microbiota and colonization resistance

Article

关键词: CHAIN FATTY-ACIDS;    CLOSTRIDIUM-DIFFICILE;    GUT MICROBIOTA;    TOXIN-B;    ALIGNMENT;    DATABASE;    GENES;    TESTS;    DIET;   

DOI  :  10.1038/s41586-021-03663-4

来源: SCIE

【 摘 要 】

Diet is a major factor that shapes the gut microbiome(1), but the consequences of diet-induced changes in the microbiome for host pathophysiology remain poorly understood. We conducted a randomized human intervention study using a very-low-calorie diet (NCT01105143). Although metabolic health was improved, severe calorie restriction led to a decrease in bacterial abundance and restructuring of the gut microbiome. Transplantation of post-diet microbiota to mice decreased their body weight and adiposity relative to mice that received pre-diet microbiota. Weight loss was associated with impaired nutrient absorption and enrichment in Clostridioides difficile, which was consistent with a decrease in bile acids and was sufficient to replicate metabolic phenotypes in mice in a toxin-dependent manner. These results emphasize the importance of diet-microbiome interactions in modulating host energy balance and the need to understand the role of diet in the interplay between pathogenic and beneficial symbionts.

【 授权许可】

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