The role of senescent cells in ageing

Review

关键词: DNA-DAMAGE RESPONSE;    ONCOGENE-INDUCED SENESCENCE;    CELLULAR SENESCENCE;    SECRETORY PHENOTYPE;    GENE-EXPRESSION;    LIFE-SPAN;    CANCER;    P53;    RAS;    HETEROCHROMATIN;   

DOI  :  10.1038/nature13193

来源: SCIE

【 摘 要 】

Cellular senescence has historically been viewed as an irreversible cell-cycle arrest mechanism that acts to protect against cancer, but recent discoveries have extended its known role to complex biological processes such as development, tissue repair, ageing and age-related disorders. New insights indicate that, unlike a static endpoint, senescence represents a series of progressive and phenotypically diverse cellular states acquired after the initial growth arrest. A deeper understanding of the molecular mechanisms underlying the multi-step progression of senescence and the development and function of acute versus chronic senescent cells may lead to new therapeutic strategies for age-related pathologies and extend healthy lifespan.

【 授权许可】

Free