The common biology of cancer and ageing

Review

关键词: ONCOGENE-INDUCED SENESCENCE;    DNA-DAMAGE RESPONSE;    LIFE-SPAN;    TELOMERE LENGTH;    C-ELEGANS;    HUMAN FIBROBLASTS;    OXIDATIVE STRESS;    HUMAN-CELLS;    SUCCINATE-DEHYDROGENASE;    GENOMIC INSTABILITY;   

DOI  :  10.1038/nature05985

来源: SCIE

【 摘 要 】

At first glance, cancer and ageing would seem to be unlikely bedfellows. Yet the origins for this improbable union can actually be traced back to a sequence of tragic - and some say unethical - events that unfolded more than half a century ago. Here we review the series of key observations that has led to a complex but growing convergence between our understanding of the biology of ageing and the mechanisms that underlie cancer.

【 授权许可】

Free