Integrative analysis of haplotype-resolved epigenomes across human tissues

Article

关键词: EMBRYONIC STEM-CELLS;    GENE-EXPRESSION;    ENHANCERS;    GENOME;    TRANSCRIPTION;    PROMOTERS;    LANDSCAPE;    BRAIN;    ATLAS;    STATE;   

DOI  :  10.1038/nature14217

来源: SCIE

【 摘 要 】

Allelic differences between the two homologous chromosomes can affect the propensity of inheritance in humans; however, the extent of such differences in the human genome has yet to be fully explored. Here we delineate allelic chromatin modifications and transcriptomes among a broad set of human tissues, enabled by a chromosome-spanning haplotype reconstruction strategy(1). The resulting large collection of haplotype-resolved epigenomic maps reveals extensive allelic biases in both chromatin state and transcription, which show considerable variation across tissues and between individuals, and allow us to investigate cis-regulatory relationships between genes and their control sequences. Analyses of histone modification maps also uncover intriguing characteristics of cis-regulatory elements and tissue-restricted activities of repetitive elements. The rich data sets described here will enhance our understanding of the mechanisms by which cis-regulatory elements control gene expression programs.

【 授权许可】

Free