Unlocking the molecular secrets of sodium-coupled transporters

Review

关键词: SEROTONIN TRANSPORTER;    NEUROTRANSMITTER TRANSPORTERS;    CRYSTAL-STRUCTURE;    MEMBRANE-TRANSPORT;    ESCHERICHIA-COLI;    BINDING-SITE;    DIFFERENT STOICHIOMETRIES;    GLYCINE TRANSPORTERS;    LEUCINE TRANSPORTER;    PERMEATION PATHWAY;   

DOI  :  10.1038/nature08143

来源: SCIE

【 摘 要 】

Transmembrane sodium-ion gradients provide energy that can be harnessed by 'secondary transporters' to drive the translocation of solute molecules into a cell. Decades of study have shown that such sodium-coupled transporters are involved in many physiological processes, making them targets for the treatment of numerous diseases. Within the past year, crystal structures of several sodium-coupled transporters from different families have been reported, showing a remarkable structural conservation between functionally unrelated transporters. These atomic-resolution structures are revealing the mechanism of the sodium-coupled transport of solutes across cellular membranes.

【 授权许可】

Free