Neuroscience in the era of functional genomics and systems biology

Review

关键词: TRANSLATIONAL PROFILING APPROACH;    GENE-COEXPRESSION NETWORK;    COMPLEX TRAIT ANALYSIS;    ADULT-MOUSE BRAIN;    CNS CELL-TYPES;    NERVOUS-SYSTEM;    PROTEIN EXPRESSION;    MOLECULAR CHARACTERIZATION;    MICROARRAY ANALYSIS;    ALZHEIMERS-DISEASE;   

DOI  :  10.1038/nature08537

来源: SCIE

【 摘 要 】

Advances in genetics and genomics have fuelled a revolution in discovery-based, or hypothesis-generating, research that provides a powerful complement to the more directly hypothesis-driven molecular, cellular and systems neuroscience. Genetic and functional genomic studies have already yielded important insights into neuronal diversity and function, as well as disease. One of the most exciting and challenging frontiers in neuroscience involves harnessing the power of large-scale genetic, genomic and phenotypic data sets, and the development of tools for data integration and mining. Methods for network analysis and systems biology offer the promise of integrating these multiple levels of data, connecting molecular pathways to nervous system function.

【 授权许可】

Free