Cellular anatomy of the mouse primary motor cortex

Article

关键词: GABAERGIC NEURONS;    DRIVER LINES;    ORGANIZATION;    RESOLUTION;    INPUT;    MICROSTIMULATION;    CONNECTIVITY;    TOMOGRAPHY;    MORPHOLOGY;    CONNECTOME;   

DOI  :  10.1038/s41586-021-03970-w

来源: SCIE

【 摘 要 】

An essential step toward understanding brain function is to establish a structural framework with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and systems can be integrated and interpreted(1). Here, as part of the collaborative Brain Initiative Cell Census Network (BICCN), we derive a comprehensive cell type-based anatomical description of one exemplar brain structure, the mouse primary motor cortex, upper limb area (MOp-ul). Usinggenetic and viral labelling, barcoded anatomy resolved by sequencing, single-neuron reconstruction, whole-brain imaging and cloud-based neuroinformaticstools, we delineated the MOp-ul in 3D and refined its sublaminar organization. We defined around two dozen projection neuron types in the MOp-ul and derived an inputoutput wiring diagram, which will facilitate future analyses of motor control circuitry across molecular, cellular and system levels. This work provides a roadmap towards a comprehensive cellular-resolution description of mammalian brain architecture.

【 授权许可】

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