Rabies screen reveals GPe control of cocaine-triggered plasticity

Article

关键词: BASAL GANGLIA;    GABAERGIC NEURONS;    DOPAMINE NEURONS;    GLOBUS-PALLIDUS;    TRANSGENIC MICE;    CIRCUITS;    OUTPUT;    INPUT;    ORGANIZATION;    BEHAVIOR;   

DOI  :  10.1038/nature23888

来源: SCIE

【 摘 要 】

Identification of neural circuit changes that contribute to behavioural plasticity has routinely been conducted on candidate circuits that were preselected on the basis of previous results. Here we present an unbiased method for identifying experience-triggered circuit-level changes in neuronal ensembles in mice. Using rabies virus monosynaptic tracing, we mapped cocaine-induced global changes in inputs onto neurons in the ventral tegmental area. Cocaine increased rabies-labelled inputs from the globus pallidus externus (GPe), a basal ganglia nucleus not previously known to participate in behavioural plasticity triggered by drugs of abuse. We demonstrated that cocaine increased GPe neuron activity, which accounted for the increase in GPe labelling. Inhibition of GPe activity revealed that it contributes to two forms of cocaine-triggered behavioural plasticity, at least in part by disinhibiting dopamine neurons in the ventral tegmental area. These results suggest that rabies-based unbiased screening of changes in input populations can identify previously unappreciated circuit elements that critically support behavioural adaptations.

【 授权许可】

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