A transfer-RNA-derived small RNA regulates ribosome biogenesis

Article

关键词: DIAMOND-BLACKFAN ANEMIA;    CELL-PROLIFERATION;    NUCLEIC-ACID;    FRAGMENTS;    REVEALS;    GENE;    EXPRESSION;    PROTEINS;    MATURATION;    EFFICIENT;   

DOI  :  10.1038/nature25005

来源: SCIE

【 摘 要 】

Transfer-RNA-derived small RNAs (tsRNAs; also called tRNA-derived fragments) are an abundant class of small non-coding RNAs whose biological roles are not well understood. Here we show that inhibition of a specific tsRNA, LeuCAG3'tsRNA, induces apoptosis in rapidly dividing cells in vitro and in a patient-derived orthotopic hepatocellular carcinoma model in mice. This tsRNA binds at least two ribosomal protein mRNAs (RPS28 and RPS15) to enhance their translation. A decrease in translation of RPS28 mRNA blocks pre-18S ribosomal RNA processing, resulting in a reduction in the number of 40S ribosomal subunits. These data establish a post-transcriptional mechanism that can fine-tune gene expression during different physiological states and provide a potential new target for treating cancer.

【 授权许可】

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