Does the Use of Rocuronium-Sugammadex Instead of Succinylcholine in Electroconvulsive Therapy Affect Seizure Duration?

Article

关键词: INDUCED NEUROMUSCULAR BLOCKADE;    LOW-DOSE ROCURONIUM;    ANESTHESIA;    REVERSAL;    RECOVERY;   

DOI  :  10.30773/pi.2022.0123

来源: SCIE

【 摘 要 】

Objective We compared retrospectively the seizure variables of electroconvulsive therapy (ECT) patients after administration of rocuronium-sugammadex or succinylcholine as a muscle relaxant with propofol anesthesia. Methods The sample comprised 134 ECT patients. The mean age was 33.6 +/- 10.48 years. Anesthesia induction was provided with propofol one mg kg-intravenously (IV) followed by succinylcholine 0.5 mg kg(-1) IV (n=68) (Group S) or rocuronium 0.3 mg kg(-1) IV (n=66) (Group R). For patients who were given rocuronium, reversal of the residual neuromuscular block was accomplished with sugammadex (1.5 mg kg(-1) IV). First session seizure variables were compared between the two groups. We also presented the clinical outcome with Clinical Global Impression-Improvement (CGI-I) and overall adverse effects. Results EEG seizure durations in Group R (55.09 +/- 36.11 s) and Group S (47.00 +/- 26.33 s) were comparable and were not significantly different (p=0.432). The clinical efficacy of ECT measured by CGI-I in both groups was comparable (p=0.075). There were no major complications or death during or after ECT. Conclusion The results of this study show that the use of rocuronium-sugammadex as a neuromuscular blocker instead of succinylcholine during ECT with propofol anesthesia produces similar results in terms of seizure variables and clinical outcomes.