The effects of a low carbohydrate diet on erectile function and serum testosterone levels in hypogonadal men with metabolic syndrome: a randomized clinical trial

BMC Endocrine Disorders

Research

Carla Martins da Costa¹  Lorenzo Miron Chiogna¹  Zilda Elizabeth de Albuquerque Santos¹  Brasil Silva Neto²  José Carlos Stumpf Souto³  Ernani Luis Rhoden⁴  Caio da Silva Schmitt⁵ 

[1] Department of Nutrition, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil;Department of Surgery, Hospital de Clínicas de Porto Alegre, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil;Post Graduate Program in Medicine: Surgical Sciences, School of Medicine, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil;Department of Urology, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil;Department of Urology, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil;Department of Surgery, School of Medicine, Universidade Federal de Ciencias da Saude de Porto Alegre, Porto Alegre, Brazil;Department of Urology, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil;Post Graduate Program in Medicine: Surgical Sciences, School of Medicine, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil;

关键词: Hypogonadism;    Metabolic syndrome;    Low carbohydrate diet;    Erectile dysfunction;    Obesity;   

DOI  :  10.1186/s12902-023-01278-6

 received in 2022-11-23, accepted in 2023-01-20,  发布年份 2023

来源: Springer

【 摘 要 】

PurposeMetabolic syndrome is a risk factor for several diseases. The relationship between metabolic syndrome and hypogonadism is well known. Our objetive is to assess whether a low carbohydrate diet can increase total serum testosterone and improve erectile function in hypogonadal men with metabolic syndrome.MethodsAn open label randomized clinical trial was conducted comparing a low carbohydrate diet and controls, during three months, in hypogonadal men with metabolic syndrome. Anthropometric measurements were evaluated as well as total serum testosterone levels, and symptoms of hypogonadism, using the ADAM and AMS scores, and sexual function using IIEF-5 score.ResultsEighteen men were evaluated. Anthropometric measures were improved only in low carbohydrate diet group. The intervention group also had a statistically increase in IIEF-5 score and a significant reduction in AMS and ADAM scores (p < 0.001). The increase in serum total testosterone levels was statistically significant in the low carbohydrate group compared to the control group as well as calculated free testosterone (p < 0.001).ConclusionsLow carbohydrate diet may increase serum levels of testosterone and improve erectile function in hypogonadal men with metabolic syndrome. However, larger studies are necessary to strongly prove the effectiveness of low carbohydrate diet in treating male hypogonadism.

【 授权许可】

CC BY   
© The Author(s) 2023