Innate immune responses in pneumonia

Pneumonia

Review

Filiz T. Korkmaz¹  Katrina E. Traber² 

[1] Department of Medicine, Division of Immunology & Infectious Disease, University of Massachusetts, Worcester, MA, USA;Pulmonary Center, Boston University School of Medicine, Boston, MA, USA;Pulmonary Center, Boston University School of Medicine, Boston, MA, USA;Department of Medicine, Boston University School of Medicine, Boston, MA, USA;

关键词: Innate immunity;    Viral pneumonia;    Bacterial pneumonia;    Macrophage;    Neutrophil;    Innate lymphocytes;    Lung epithelium;    Lung endothelium;    Extracellular matrix;   

DOI  :  10.1186/s41479-023-00106-8

 received in 2022-02-09, accepted in 2023-01-05,  发布年份 2023

来源: Springer

【 摘 要 】

The lungs are an immunologically unique environment; they are exposed to innumerable pathogens and particulate matter daily. Appropriate clearance of pathogens and response to pollutants is required to prevent overwhelming infection, while preventing tissue damage and maintaining efficient gas exchange. Broadly, the innate immune system is the collection of immediate, intrinsic immune responses to pathogen or tissue injury. In this review, we will examine the innate immune responses of the lung, with a particular focus on their role in pneumonia. We will discuss the anatomic barriers and antimicrobial proteins of the lung, pathogen and injury recognition, and the role of leukocytes (macrophages, neutrophils, and innate lymphocytes) and lung stromal cells in innate immunity. Throughout the review, we will focus on new findings in innate immunity as well as features that are unique to the lung.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 2