期刊论文详细信息
BMC Medical Genomics
Pan-cancer analysis of the prognostic and immunological role of SNX29: a potential target for survival and immunotherapy
Research
Fanghan Li1  Jiangwei Xiao2  Zilin Liu2  Chengfei Xu2  Chuanjing Yan2 
[1] Department of Gastrointestinal Surgery, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, 610500, Chengdu, People’s Republic of China;School of Clinical Medicine, Chengdu Medical College, 610500, Chengdu, People’s Republic of China;Department of Gastrointestinal Surgery, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, 610500, Chengdu, People’s Republic of China;School of Clinical Medicine, Chengdu Medical College, 610500, Chengdu, People’s Republic of China;First Affiliated Hospital of Chengdu Medical College, 610500, Chengdu, People’s Republic of China;
关键词: Pan-cancer;    Immune infiltration;    Prognosis prediction;    Microsatellite instability;    Tumor mutation load;    Drug sensitivity;   
DOI  :  10.1186/s12920-023-01466-2
 received in 2022-07-25, accepted in 2023-02-21,  发布年份 2023
来源: Springer
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【 摘 要 】

BackgroundThere is growing evidence that the SNX family is critical for clinical prognosis, immune infiltration and drug sensitivity in many types of tumors. The relationships between the SNX29 gene and clinical prognosis as well as pan-cancer cell infiltration and drug sensitivity have not been fully elucidated.MethodsIn the current study, we explored the correlation between SNX29 expression and 33 types of malignancies via TCGA and GTEx. The relationship between SNX29 expression and prognostic outcome in the pan-caner cohort was also analyzed. Immune infiltration, microsatellite instability, tumor mutational burden and potential therapeutic targets of SNX29 were investigated by analyzing public databases.ResultsThe expression of SNX29 was found to be significantly upregulated in most tumor tissues compared to normal tissues. SNX29 expression was associated with prognosis and clinical stage. In the immune infiltration analysis, a significant relationship was found between SNX29 expression and the level of immune infiltration. In addition, we found associations between the SNX29 gene and tumor mutation burden, microsatellite instability, immunoinhibition-related genes and autophagy-related genes. Finally, the expression of SNX29 was significantly associated with the sensitivity of various tumor cell lines to 8 antitumor drugs. These results suggest that SNX29 expression is important in determining the progression, immune infiltration and drug sensitivity of various cancers.ConclusionThis study provides novel insights into the potential pan-cancer targets of SNX29.

【 授权许可】

CC BY   
© The Author(s) 2023

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