期刊论文详细信息
Cancer Cell International
Pan-cancer analysis identifies LMNB1 as a target to redress Th1/Th2 imbalance and enhance PARP inhibitor response in human cancers
Bo Jiang1  Wenmin Cao1  Hongqian Guo1  Meng Ding1  Jingyan Shi1  Xiaozhi Zhao1  Yingqiang Lu1  Wenli Diao1  Lin Du1  Haixiang Qin1  Haoli Yin1  Xuefeng Qiu1  Wei Chen1 
[1] Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University;
关键词: LMNB1;    Pan-cancer;    Survival;    Immune infiltration;    Homologous recombination repair;   
DOI  :  10.1186/s12935-022-02467-4
来源: DOAJ
【 摘 要 】

Abstract Background Emerging evidence suggests that LMNB1 is involved in the development of multiple cancer types. However, there is no study reporting the potential role of LMNB1 in a systematic pan-cancer manner. Methods The gene expression level and potential oncogenic roles of LMNB1 in The Cancer Genome Atlas (TCGA) database were analyzed with Tumor Immune Estimation Resource version 2 (TIMER2.0), Gene Expression Profiling Interactive Analysis version 2 (GEPIA2), UALCAN and Sangerbox tools. Pathway enrichment analysis was carried out to explore the possible mechanism of LMNB1 on tumorigenesis and tumor progression. The therapeutic effects of LMNB1 knockdown combined with PARP inhibition on human cancers were further investigated in vitro. Results LMNB1 upregulation is generally observed in the tumor tissues of most TCGA cancer types, and is verified in kidney renal clear cell carcinoma using clinical specimens of our institute. High level of LMNB1 expression usually predicts poor overall survival and disease free survival for patients with tumors. Mechanically, LMNB1 level is positively correlated with CD4+ Th2 cell infiltration and DNA homologous recombination repair gene expression. In vitro experiments reveal that targeting LMNB1 has a synergistic effect on prostate cancer with PARP inhibitor treatment. Conclusions LMNB1 is a biomarker of CD4+ Th2 cell infiltration and DNA homologous recombination repair in human cancers. Blockage of LMNB1 combined with PARP inhibitor treatment could be a promising therapeutic strategy for patients with cancers.

【 授权许可】

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