Erroneous detection of desensitization doses in the prevention of hypersensitivity reactions

BMC Research Notes

Research Note

Razvan Costin Stan¹ 

[1] Department of Biomedical Sciences, Chonnam National University, Seoyang-ro 264, 58128, Hwasun, South Korea;

关键词: Drug desensitization;    Signal processing;    IgE;    Aliasing;    Allergens;   

DOI  :  10.1186/s13104-023-06278-2

 received in 2022-07-22, accepted in 2023-01-23,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundDesensitization protocols have empirically established their efficacy and safety in eliminating most of the hypersensitivity reactions to drugs and other allergens. Without such procedures, the offending drugs can otherwise be lethal, for some patients, when singularly administered at therapeutic doses. These binding events and the subsequent signaling cascades have been extensively modulated by different desensitization methods, without any clear explanation as to why it is necessary to use increasing allergen doses.PurposeTo use a novel theoretical approach in order to model the desensitization algorithms currently in practice, that seeks to shed light on the mechanism behind their clinical efficacy.MethodAn approach using signal processing concepts is applied in this work to introduce aliasing as the erroneous detection of higher drug doses responsible for the efficacy of desensitization procedures.ResultsAvailable experimental data is modeled and correct predictions as to the efficacy of the drug treatment procedures are produced.ConclusionsDesensitization algorithms may benefit from using concepts from signal processing theory in order to avoid hypersensitivity reactions.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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