Reduced contrast sensitivity function correlated with superficial retinal capillary plexus impairment in early stage of dysthyroid optic neuropathy

Eye and Vision

Research

Zhong-Lin Lu¹  Mengting Wang²  Mengyuan Gao²  Xiaozhou Hu²  Mingna Xu²  Jie Ye²  Haochen Jin²  Yunhai Tu²  Zihui Liu²  Weijie Liu²  Fang Hou²  Wencan Wu³ 

[1] Division of Arts and Sciences, NYU Shanghai, Shanghai, China;Center for Neural Science and Department of Psychology, New York University, New York, USA;NYU-ECNU Institute of Brain and Cognitive Science, NYU Shanghai, Shanghai, China;The Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, 325027, Wenzhou, China;The Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, 325027, Wenzhou, China;Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), 325000, Wenzhou, Zhejiang, China;

关键词: Contrast sensitivity function;    Visual impairments;    Superficial retinal capillary plexus;    Thyroid-associated ophthalmopathy;    Dysthyroid optic neuropathy;   

DOI  :  10.1186/s40662-023-00328-3

 received in 2022-07-06, accepted in 2023-01-08,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundTo assess the accuracy of contrast sensitivity function (CSF) in detecting dysthyroid optic neuropathy (DON) at an early stage in thyroid-associated ophthalmopathy (TAO) patients and to examine potential factors that may be linked to early visual impairments in these individuals.MethodsA total of 81 TAO patients (50 non-DON and 31 DON), and 24 control subjects participated in the study. CSF was measured with the quick CSF (qCSF) method. Optical coherence tomography angiography (OCTA) images of the ganglion cell complex layer (GCCL), superficial and deep retinal capillary plexuses (SRCP and DRCP) in a 3 mm diameter area around the macula were evaluated.ResultsCompared with the controls, the area under the log contrast sensitivity function (AULCSF) and SRCP density were significantly reduced in non-DON and DON patients (all P < 0.05). The GCCL thickness of the DON patients was thinner than that of the controls and non-DON patients (all P < 0.05). The AULCSF was significantly correlated with spherical equivalent refractive error, muscle index, SRCP density and GCCL thickness in TAO patients, respectively (all P < 0.05). However, stepwise multi-regression analysis showed that the AULCSF was only significantly correlated with SRCP density (P < 0.001). Receiver operating characteristic curve analysis showed that the AULCSF produced the most accurate discrimination between non-DON and DON patients from the controls (AUC = 0.831, 0.987, respectively; all P < 0.001).ConclusionsCSF change in the early stage of DON is related to SRCP density. It can be an early indicator of visual impairments associated with DON in TAO patients.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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