Epigenetic aging in patients diagnosed with coronary artery disease: results of the LipidCardio study

Clinical Epigenetics

Research

Ulf Landmesser¹  Valentin Max Vetter²  Verena Laura Banszerus²  Maximilian König²  Ilja Demuth³ 

[1] Department of Cardiology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin (CBF), Berlin, Germany;Berlin Institute of Health (BIH), Deutsches Zentrum Für Herzkreislaufforschung (DZHK), Partner Site Berlin, Berlin, Germany;Department of Endocrinology and Metabolic Diseases (Including Division of Lipid Metabolism), Biology of Aging Working Group, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany;Department of Endocrinology and Metabolic Diseases (Including Division of Lipid Metabolism), Biology of Aging Working Group, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany;BCRT - Berlin Institute of Health Center for Regenerative Therapies, Charité - Universitätsmedizin Berlin, Berlin, Germany;

关键词: Coronary artery disease;    Atherosclerosis;    Cardiovascular disease;    Biomarkers;    Epigenetics;    Angiography;    LipidCardio study;    Berlin Aging Study II;    BASE-II;   

DOI  :  10.1186/s13148-023-01434-8

 received in 2022-11-16, accepted in 2023-01-23,  发布年份 2023

来源: Springer

【 摘 要 】

IntroductionPeople age biologically at different rates. Epigenetic clock-derived DNA methylation age acceleration (DNAmAA) is among the most promising markers proposed to assess the interindividual differences in biological age. Further research is needed to evaluate the characteristics of the different epigenetic clock biomarkers available with respect to the health domains they reflect best.MethodsIn this study, we have analyzed 779 participants of the LipidCardio study (mean chronological age 69.9 ± 11.0 years, 30.6% women) who underwent diagnostic angiography at the Charité University Hospital in Berlin, Germany. DNA methylation age (DNAm age) was measured by methylation-sensitive single nucleotide primer extension (MS-SNuPE) and calculated with the 7-CpG clock. We compared the biological age as assessed as DNAmAA of participants with an angiographically confirmed coronary artery disease (CAD, n = 554) with participants with lumen reduction of 50% or less (n = 90) and patients with a normal angiogram (n = 135).ResultsParticipants with a confirmed CAD had on average a 2.5-year higher DNAmAA than patients with a normal angiogram. This association did not persist after adjustment for sex in a logistic regression analysis. High-density lipoprotein, low-density lipoprotein, triglycerides, lipoprotein (a), estimated glomerular filtration rate, physical activity, BMI, alcohol consumption, and smoking were not associated with DNAmAA.ConclusionThe association between higher DNAmAA and angiographically confirmed CAD seems to be mainly driven by sex.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 7