Is there a causal nexus between COVID-19 infection, COVID-19 vaccination, and Guillain-Barré syndrome?

European Journal of Medical Research

Review

Yong Fang¹  Kangding Liu¹  Xiujuan Wu¹  Xiaoxiao Zheng¹  Jie Zhu²  Yanna Song³  Shan Liu⁴ 

[1] Department of Neurology, Neuroscience Center, The First Hospital of Jilin University, Jilin University, Xinmin Street 1#, 130021, Changchun, China;Department of Neurology, Neuroscience Center, The First Hospital of Jilin University, Jilin University, Xinmin Street 1#, 130021, Changchun, China;Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Karolinska University Hospital, Solna, Stockholm, Sweden;Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;The Second Hospital of Jilin University, Jilin University, Changchun, China;

关键词: Guillain-Barré syndrome;    SARS-CoV-2;    COVID-19;    Vaccination;    Epidemiology;   

DOI  :  10.1186/s40001-023-01055-0

 received in 2022-09-14, accepted in 2023-02-08,  发布年份 2023

来源: Springer

【 摘 要 】

Guillain-Barré syndrome (GBS) is an immune-mediated inflammatory polyradiculoneuropathy, which commonly leads to a very high level of neurological disability. Especially, after the global outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the causation between GBS and SARS-CoV-2 infection and the coronavirus disease 2019 (COVID-19) vaccination have aroused widespread concern. In the review, we analyzed the impacts of SARS-CoV-2 infection and COVID-19 vaccination on GBS globally, aiming to further understand the characteristics of GBS associated with COVID-19. Based on the electrophysiological data, patients suffering from GBS related to COVID-19 manifested as an acute inflammatory demyelinating polyneuropathy (AIDP). Moreover, we summarized the current findings, which may evidence GBS linking to SARS-CoV-2 infection and COVID-19 vaccination, and discussed the underlying mechanisms whether and how the SARS-CoV-2 virus and COVID-19 vaccination can induce GBS and its variants.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 3