Guillain-Barré Syndrome in Patient With SARS-CoV-2 PCR Positivity Treated Successfully With Therapeutic Exchange Plasma: A First Case Report From Vietnam

Frontiers in Neurology

Sy Duong-Quy²  Duc Huynh-Truong-Anh⁴  Tien Nguyen-Quang⁴  Thanh Nguyen-Thi-Kim⁴  Thanh Nguyen-Chi⁴  Quynh Tran-Xuan⁵  Carine Ngo⁶  Vinh Nguyen-Nhu⁷  Timothy Craig⁸ 

[1] Department of Clinical Research, Biomedical Research Center, Lam Dong Medical College, Dalat, Vietnam;Department of Expert Consultation, Faculty of Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh, Vietnam;Department of Family Medicine, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh, Vietnam;Department of Intensive Care Unit, Covid-19 Unit of Phu Chanh, Binh Duong General Hospital, Binh Duong, Vietnam;Department of Internal Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam;Department of Pathology, Institute Gustave Roussy, Villejuif, France;Department of Respiratory Functional Exploration. University Medical Center, Ho Chi Minh, Vietnam;Division of Pulmonary, Allergy and Critical Care Medicine, Penn State College of Medicine, Hershey, PA, United States;

关键词: Guillain-Barré syndrome;    SARS-CoV-2;    COVID-19;    MRC scale;    therapeutic plasma exchange;   

DOI  :  10.3389/fneur.2022.868667

来源: DOAJ

【 摘 要 】

Since the first case of Guillain-Barré syndrome (GBS)-associated SARS-CoV-2 (COVID-19) infection reported in 2020, a series of cases have been published in some countries. In this case report, we present a young patient with GBS, whose clinical and laboratory data were appropriate for the diagnosis of GBS due to COVID-19 infection. Neurological examination revealed the muscular weakness of lower limbs with Medical Research Council (MRC) scale of 2/5 associated with diminished reflexes. Laboratory studies showed the positive nasal swab RT-PCR test for COVID-19, leukopenia, increased ferritin and LDH levels, normal electrolyte and liver and kidney function, and normal chest X-ray. The result of cerebrospinal fluid showed the albuminocytologic dissociation. The patient was treated with remdesivir, dexamethasone, anticoagulation, and therapeutic plasma exchange (TPE). Patient's muscle weakness was significantly improved after 1 week of admission. He was discharged at 23rd days of hospitalization and followed-up in the out-patients department.

【 授权许可】

Unknown