Risk factors for self-reported medication adherence in community-dwelling older patients with multimorbidity and polypharmacy: a multicenter cross-sectional study

BMC Geriatrics

Research

Yongpei Yu¹  Tiantian He¹  Xin Wang²  Wenchao Li³  Ruixue Zhang³  Su Su³  Yan Zeng³  Qian Ding³  Suying Yan³  Jiaming Liu³  Lan Zhang³  Zimin Wang³  Xiaolin Yue⁴ 

[1] Department of Biostatistics, Peking University Clinical Research Institution, Beijing, China;Department of Medical Affairs, Xuanwu Hospital, Capital Medical University, Beijing, China;Department of Pharmacy, Xuanwu Hospital, Capital Medical University, Beijing, China;Ethics Committee, Xuanwu Hospital, Capital Medical University, Beijing, China;

关键词: Medication adherence;    Potentially inappropriate medication;    Multimorbidity;    Polypharmacy;    Older adults;   

DOI  :  10.1186/s12877-023-03768-7

 received in 2022-10-13, accepted in 2023-01-23,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundMedication nonadherence is a significant public health problem as it contributes to poor clinical outcomes and increased healthcare costs. Older patients with multimorbidity and polypharmacy often have low medication adherence. These patients also have a high prevalence of potentially inappropriate medication (PIM) use.AimTo explore risk factors related to medication nonadherence in older patients with multimorbidity and polypharmacy and examine the association between medication nonadherence and PIM use.MethodA multicenter cross-sectional study was conducted from May to December 2019 in 16 tertiary hospitals from 12 provinces and cities in China. Data were collected from outpatients 65 years or older with multimorbidity and polypharmacy. The PIMs were evaluated using the 2019 Beers Criteria. Self-reported medication adherence was assessed using the Visual Analog Scale (VAS).ResultsA total of 773 outpatients were recruited. The prevalence of medication nonadherence was 31.8%. In the univariate analysis, nonadherence was significantly associated with sex, cognitive impairment, stroke, visiting the same physicians, self-administration of medication, the percentage of drug costs ≥ 10% of the medical expenses, and PIMs for the alimentary tract and metabolism. In the multivariate analysis, the results almost paralleled those of the univariate associations. Notably, the use of PIM was significantly associated with medication adherence.ConclusionSeveral factors that influence medication adherence were identified. Targeted interventions can be implemented to improve medication adherence, such as encouraging self-administering medications and reducing medication expenses.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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