Effect of nanoparticles on gouty arthritis: a systematic review and meta-analysis

BMC Musculoskeletal Disorders

Research

Xuance Xiong¹  Yingzhi Li²  Saikun Wang³  Yingze Guo³  Jing Mao³  Lirong Guo³  Ruiting Zhu³  Yangyang Lei³  Yirou Niu³  Wei Zhou⁴ 

[1] Medical College, Beihua University, 132013, Jilin, Jilin, China;Orthpoeadic Medical Center, Jilin University Second Hospital, 130041, Changchun, Jilin, China;School of Nursing, Jilin University, 130021, Changchun, Jilin, China;The First Hospital of Jilin University, 130021, Changchun, Jilin, China;

关键词: Nanoparticles;    Uric acid;    Gouty arthritis;    Animal experiment;    Meta-analysis;   

DOI  :  10.1186/s12891-023-06186-3

 received in 2022-08-24, accepted in 2023-01-23,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectiveThe purpose of this study was to explore the effects of nanoparticles on gouty arthritis, and to provide evidence for the preclinical application of nanoparticles in gouty arthritis and ideas for nanomedicine improvement for nanoparticle researchers.MethodsFive databases including the Cochrane Library, PubMed, Scopus, Web of Science, and Embase were searched for eligible studies until April 2022. The quality of the selected studies was assessed by SYRCLE’s risk of bias (RoB) tool, and the random-effects model was used to calculate the overall effect sizes of weighted mean differences (WMD).ResultsTen studies met the inclusion criteria. Results showed that nanoparticles were effective in reducing uric acid levels (WMD: -4.91; 95% confidence interval (CI): − 5.41 to − 4.41; p < 0.001), but were not better than allopurinol (WMD: -0.20; 95% CI: − 0.42 to 0.02; p = 0.099). It was worth noting that the nanoparticles were safer than allopurinol. Subgroup analyses indicated that nanoparticle encapsulated substance, animal species, nanoparticle dosage, animal quantity, and animal gender were all sources of heterogeneity.ConclusionThe nanoparticles are safe medications for gouty arthritis which can effectively reduce uric acid levels in rodents. Although the results are still uncertain, it is expected to have certain clinical application value. The nanoparticles may be the preclinical medications for gouty arthritis in the future.

【 授权许可】

CC BY   
© The Author(s) 2023

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