RETRACTED ARTICLE: Long noncoding RNA SNHG1 promotes TERT expression by sponging miR-18b-5p in breast cancer

Cell & Bioscience

Research

Lei Zhang¹  Qin Wang¹  Lei Liu¹  Yujuan Kang¹  Shouping Xu¹  Xin Zhang¹  Jiena Liu¹  Lin Wan¹  Yanling Yin¹  Hao Wu¹  Da Pang² 

[1] Department of Breast Surgery, Harbin Medical University Cancer Hospital, 150040, Harbin, China;Department of Breast Surgery, Harbin Medical University Cancer Hospital, 150040, Harbin, China;Heilongjiang Academy of Medical Sciences, Harbin, China;

关键词: SNHG1;    TERT;    Breast cancer;    Competing endogenous RNA;    E2F1;   

DOI  :  10.1186/s13578-021-00675-5

 received in 2021-02-27, accepted in 2021-08-03,  发布年份 2021

来源: Springer

【 摘 要 】

BackgroundLong noncoding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) plays a positive role in the progression of human malignant tumors. However, the molecular mechanism of SNHG1 remains elusive in breast cancer.ResultsLncRNA SNHG1 was upregulated and had a positive relationship with poor prognosis according to bioinformatics analysis in pan-cancer including breast cancer. Silencing SNHG1 inhibited tumorigenesis in breast cancer both in vitro and in vivo. Mechanistically, SNHG1 functioned as a competing endogenous RNA (ceRNA) to promote TERT expression by sponging miR-18b-5p in breast cancer. miR-18b-5p acted as a tumor repressor in breast cancer. Moreover, the combination of SNHG1 knockdown and TERT inhibitor administration showed a synergistic inhibitory effect on breast cancer growth in vivo. Finally, E2F1 as a transcription factor, binding to SNHG1 promoter and enhanced SNHG1 transcription in breast cancer.ConclusionsOur results provide a comprehensive understanding of the oncogenic mechanism of lncRNA SNHG1 in breast cancer. Importantly, we identified a novel E2F1–SNHG1–miR-18b-5p–TERT axis, which may be a potential therapeutic target for breast cancer. Our results also provided a potential treatment for breast cancer when knockdown SNHG1 and TERT inhibitor administration simultaneously.

【 授权许可】

CC BY   
© The Author(s) 2021

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