Factors for poor oral health in long-term childhood cancer survivors

BMC Oral Health

Research

Ryan Sun¹  Tushar Patni²  Yimei Li²  Sue Kaste³  Kirsten K. Ness⁴  Leslie L. Robison⁴  Ana Neumann⁵  Liang Zhu⁶  Melissa M. Hudson⁷  Chun-Teh Lee⁸ 

[1] Department of Biostatistics, MD Anderson Cancer Center, Houston, TX, USA;Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, TN, USA;Department of Diagnostic Imaging, St. Jude Children’s Research Hospital, Memphis, TN, USA;Department of Epidemiology, St. Jude Children’s Research Hospital, Memphis, TN, USA;Department of General Practice and Dental Public Health, The University of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA;Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA;Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN, USA;Department of Periodontics and Dental Hygiene, The University of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA;

关键词: Cohort studies;    Dental care;    Dental caries;    Mouth diseases;    Periodontal diseases;    Radiation effects;   

DOI  :  10.1186/s12903-023-02762-0

 received in 2022-09-02, accepted in 2023-01-23,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundSurvivors of childhood cancer are at risk for therapy-related dental diseases. The purpose of the study was to investigate the associations between clinical, socioeconomic, and demographic factors and oral diseases in the St. Jude Lifetime Cohort (SJLIFE) participants.MethodsWe performed a retrospective medical chart review and evaluated longitudinal self-reported dental outcomes in 4856 childhood cancer survivors and 591 community controls participating in the St. Jude Lifetime Cohort (SJLIFE) study. Univariate and multivariable logistic regression models were used to assess the impact of socioeconomic factors, treatment exposures and patient demographics on dental outcomes.ResultsCancer survivors were more likely to report microdontia (odds ratio (OR) = 7.89, 95% confidence interval (CI) [4.64, 14.90]), abnormal root development (OR = 6.19, CI [3.38, 13.00]), hypodontia (OR = 2.75, CI [1.83, 4.33]), enamel hypoplasia (OR = 4.24, CI [2.9, 6.49]), xerostomia (OR = 7.72, CI [3.27, 25.10]), severe gingivitis (OR = 2.04, CI [1.43, 3.03]), and ≥ 6 missing teeth (OR = 3.73, CI [2.46, 6.00]) compared to controls without cancer history. Survivors who received classic alkylating agents (OR = 1.6, CI [1.36, 1.88]), anthracycline antibiotics (OR = 1.22, CI [1.04, 1.42] or radiation therapy potentially exposing the oral cavity (OR = 1.48, CI [1.26, 1.72]) were more likely to report at least one dental health problem after controlling for socioeconomic factors, age at last follow-up and diagnosis, other treatment exposures, and access to dental services. Survivors who had radiation therapy potentially exposing the oral cavity (OR = 1.52, CI [1.25, 1.84]) were also more likely to report at least one soft tissue abnormality after controlling for socioeconomic factors, age at last follow-up and diagnosis, other treatment exposures, and access and utilization of dental services.ConclusionsChildhood cancer survivors have a higher prevalence of oral-dental abnormalities than the controls without a cancer history. Cancer treatment, socioeconomic factors, and access to oral health care contribute to the prevalence of dental abnormalities.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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