Galectin-3 and sST2: associations to the echocardiographic markers of the myocardial mechanics in systemic sclerosis – a pilot study

Cardiovascular Ultrasound

Research

Margit Tőkés-Füzesi¹  László Czirják²  Vivien Vértes³  Ágnes Nógrádi³  Adél Porpáczy³  András Komócsi³  Máté Hajdu³  Réka Faludi³ 

[1] Department of Laboratory Medicine, Medical School, University of Pécs, Ifjúság út 13, H-7624, Pécs, Hungary;Department of Rheumatology and Immunology, Medical School, University of Pécs, Akác u. 1, H-7632, Pécs, Hungary;Heart Institute, Medical School, University of Pécs, Ifjúság út 13, H-7624, Pécs, Hungary;

关键词: Systemic sclerosis;    Myocardial fibrosis;    Galectin-3;    sST2;    Global longitudinal strain;    Diastolic dysfunction;   

DOI  :  10.1186/s12947-022-00272-7

 received in 2021-08-16, accepted in 2022-01-05,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundProgressive cardiac fibrosis is the central aspect of the myocardial involvement in systemic sclerosis (SSc). We hypothesized that circulating biomarkers of the cardiac fibrosis may be useful in the early diagnosis of the cardiac manifestation in this disease. Thus, we investigated the potential correlations between the levels of galectin-3, soluble suppression of tumorigenicity-2 (sST2) and the echocardiographic markers of the myocardial mechanics in SSc patients.MethodsForty patients (57.3 ± 13.7 years, 36 female) were investigated. In addition to the conventional echocardiography, tissue Doppler and speckle tracking-derived strain techniques were used to assess the function of both ventricles and atria. To estimate the correlations between galectin-3 and sST2 levels and the echocardiographic variables, partial correlation method was used with age as correcting factor.ResultsIn age adjusted analysis galectin-3 level showed significant correlation with left ventricular global longitudinal strain (r = 0.460, p = 0.005); grade of left ventricular diastolic dysfunction (r = 0.394, p = 0.013); septal e’ (r = − 0.369, p = 0.021); septal E/e’ (r = 0.380, p = 0.017) and with the grade of mitral regurgitation (r = 0.323, p = 0.048). No significant correlation was found between sST2 levels and the echocardiographic variables.ConclusionsGalectin-3 levels, but not sST2 levels show significant correlation with the parameters of the left ventricular systolic and diastolic function. Galectin-3 may be a useful biomarker for the screening and early diagnosis of SSc patients with cardiac involvement.

【 授权许可】

CC BY   
© The Author(s) 2022. corrected publication 2023

【 图 表 】

Fig. 7