Silent myocarditis in systemic sclerosis detected by cardiovascular magnetic resonance using Lake Louise criteria

BMC Cardiovascular Disorders

Research Article

John Raftakis¹  Georgia Karabela²  Gikas Katsifis²  Efthymios Stavropoulos²  Michel Noutsias³  George Markousis-Mavrogenis⁴  Genovefa Kolovou⁴  Sophie Mavrogeni⁴  Loukia Koutsogeorgopoulou⁵  Sotiris Plastiras⁵ 

[1] Asklipion Voulas Hospital, Athens, Greece;Athens Naval Hospital, Athens, Greece;Department of Internal Medicine III, Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, Martin-Luther-University Halle, Ernst-Grube-Straße 40, D-06120, Halle (Saale), Germany;Onassis Cardiac Surgery Center, 50 Esperou Street, 175-61 P.Faliro, Athens, Greece;Pathophysiology Department, Laikon Hospital, Athens, Greece;

关键词: Cardiovascular magnetic resonance;    Systemic sclerosis;    Myocarditis;    Myocardial fibrosis;   

DOI  :  10.1186/s12872-017-0619-x

 received in 2017-03-09, accepted in 2017-07-05,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundSystemic sclerosis (SSc) is an autoimmune disease characterized by microvascular abnormalities, inflammation and fibrosis. We hypothesized that myocarditis may be diagnosed in asymptomatic SSc, undergoing routine cardio-vascular magnetic resonance (CMR) for fibrosis assessment, using the Lake Louise criteria: T2 ratio, early (EGE) and late gadolinium enhanced (LGE) images.MethodsEighty-two asymptomatic SSc, diagnosed according to American College of Rheumatology criteria, aged 43 ± 5 yrs., 62 with diffuse (dSSc) and 20 with localized (lSSc) systemic sclerosis were evaluated by CMR, performed at 1.5 T scanner, according to Lake Louise criteria.ResultsCMR documented normal biventricular function in all SSc. However, 7/62 (11.2%) with dSSc and 2/20 (10%) with lSSc, had CMR signs of myocarditis according to Lake Louise criteria, without any clinical cardiac symptom. In these 9 patients, T2 ratio, EGE ratio and LGE (positive in all 9 SSc) were 2.8 ± 0.5%, 8 ± 3% and 5 ± 3% of LV mass, respectively. No correlation between CMR and blood inflammatory indices (C-reactive protein and erythrocyte sedimentation rate), cardiac troponin T, disease characteristics or type of SSc was identified. A repeat CMR at 6 months, after treatment with prednisone and azathioprine, showed normalisation of the acute inflammation CMR indices.ConclusionsSilent myocarditis may be diagnosed using the Lake Louise paper criteria in SSc patients without cardiac symptoms, has no correlation with blood inflammatory indices, cardiac troponin or disease characteristics. CMR is a promising tool to diagnose silent myocarditis in SSc and monitor the response to immunosuppressive treatment.

【 授权许可】

CC BY   
© The Author(s). 2017