Association between the stress hyperglycemia ratio and severity of coronary artery disease under different glucose metabolic states

Cardiovascular Diabetology

Research

Liao Zhang¹  Yunhe Wu¹  Ganggang Wu¹  Haiyan Song¹  Ying Qu¹  Jiahui Xiu¹  Jing Bai¹  Yu Zhang¹ 

[1] Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China;

关键词: Stress hyperglycemia ratio;    Coronary artery disease;    Normal glucose regulation;    Pre-diabetes mellitus;    Diabetes mellitus;   

DOI  :  10.1186/s12933-023-01759-x

 received in 2023-01-03, accepted in 2023-02-01,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundStress hyperglycemia ratio (SHR) is significantly related to adverse cardiovascular clinical outcomes and increased in-hospital mortality. However, the relationship between SHR and coronary artery disease (CAD) severity has hitherto not been reported. This study sought to clarify the relationship between the SHR and CAD severity of individuals with different glucose metabolic statuses.MethodsA retrospective analysis was performed on 987 patients who underwent coronary angiography (CAG) from October 2020 to May 2022. Based on CAG results, patients were divided into single-vessel CAD and multi-vessel CAD groups. All subjects were stratified into three groups according to the tertiles of the SHR (T1 group: SHR < 0.930; T2 group: 0.930 ≤ SHR < 1.154; T3 group: 1.154 ≤ SHR). Moreover, according to glucose metabolism status, study subjects were divided into normal glucose regulation (NGR), pre-diabetes mellitus (pre-DM) and diabetes mellitus (DM) groups. Finally, the correlation between SHR and CAD severity was analyzed by logistic regression analysis and receiver operating characteristic (ROC) curve.ResultsThe results showed significantly higher SHR in the multi-vessel CAD group than in the single-vessel group. Logistic regression analysis showed that SHR was an independent risk factor for multi-vessel CAD when used as a continuous variable (OR, 4.047; 95% CI 2.137–7.663; P < 0.001). After adjusting for risk factors, the risk of multi-vessel CAD in the T2 and T3 groups was 1.939-fold (95% CI 1.341–2.804; P < 0.001) and 1.860-fold (95% CI 1.272–2.719; P = 0.001) higher than in the T1 group, respectively. The area under the curve (AUC) of ROC plots was 0.613 for SHR. In addition, SHR was significantly correlated with an increased risk of multi-vessel CAD in the pre-DM and DM groups.ConclusionsOur study indicated that SHR was significantly correlated with the risk of multi-vessel CAD and predicted CAD severity, especially in pre-DM and DM patients.

【 授权许可】

CC BY   
© The Author(s) 2023