期刊论文详细信息
BMC Public Health
Changing incidence of hepatitis B and persistent infection risk in adults: a population-based follow-up study from 2011 in China
Research
Taiwen Zeng1  Tianxian Wu1  Yin Dong1  Lushun Jiang2  Bing Ruan2  Zhuoqi Lou2  Chunting Peng2  Chensi Wu3  Xiaolan Xu3 
[1] People’s Hospital Medical Community of Yuhuan County, 318000, Taizhou, China;State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 310000, Hangzhou, China;State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 310000, Hangzhou, China;Zhejiang Provincial Peoples’s Hospital, 310000, Hangzhou, China;
关键词: Asymptomatic infections;    Carrier State;    Epidemiology;    Hepatitis B virus;    Immunization;   
DOI  :  10.1186/s12889-023-15130-y
 received in 2022-11-08, accepted in 2023-01-24,  发布年份 2023
来源: Springer
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【 摘 要 】

BackgroundThis study aimed to estimate hepatitis B incidence and chronicity risk in rural adults in China under the background of eliminating viral hepatitis.MethodsHepatitis B surface antigen (HBsAg) screening was conducted every 2 years in demonstration areas since 2011. Individuals with baseline HBsAg-negative were included. Incidence was calculated as the number of HBsAg-positive cases divided by the total person-times. HBsAg-positive individuals were followed up to study the persistent infection (> 6 months), chronic infection (> 12 months), and recovery with hepatitis B surface antibody (anti-HBs). The chi-square test and cox proportional regression analysis were performed.ResultsThere were 8,942 incident cases over 2,138,532 person-years, yielding an average incidence of 0.42 per 100 person-years. HBV incidence decreased rapidly in both genders and all age groups and then kept stable. Male gender, low population density, low gross domestic product per capita, and islanders were associated with higher incidence. Of the positive cases, 4,989 (55.8%) patients were followed up. The persistent infection, chronic infection, and recovery with anti-HBs rates were 32.3%, 31.0%, and 31.4%, respectively. Persistent or chronic infection was more common in younger adults and males, while seroconversion had no concern with gender or age.ConclusionsHBV incidence in adult rural residents was decreasing and stayed low. The chronicity rate was relatively high and protective antibodies were induced in only one third. The importance of population-based screening and vaccination for susceptible individuals should be addressed.

【 授权许可】

CC BY   
© The Author(s) 2023

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