Chondroitin sulfate alleviates osteoporosis caused by calcium deficiency by regulating lipid metabolism

Nutrition & Metabolism

Research

Xinyiran Du¹  Tianshu Liu²  Xiaodong He³  Huimin Li⁴  Hai Yu⁵  Shuai Wang⁶ 

[1] College of Stomatology, Jining Medical University, 272067, Jining, Shandong, China;Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, 250012, Jinan, Shandong, China;Institute for Medical Dataology, Shandong University, National Institute of Health Data Science of China, 250012, Jinan, Shandong, China;Department of Physical and Chemical Inspection, School of Public Health, Cheeloo College of Medicine, Shandong University, 250012, Jinan, Shandong, China;Institute for Medical Dataology, Shandong University, National Institute of Health Data Science of China, 250012, Jinan, Shandong, China;Department of Physical and Chemical Inspection, School of Public Health, Cheeloo College of Medicine, Shandong University, 250012, Jinan, Shandong, China;National Human Genetic Resources Center; National Research Institute for Health and Family Planning, Chinese Academy of Medical Sciences & Peking Union Medical College, 100730, Beijing, China;Division of Cancer RNA Research, National Cancer Center Research Institute, 104-0045, Tokyo, Japan;Institute for Medical Dataology, Shandong University, National Institute of Health Data Science of China, 250012, Jinan, Shandong, China;Institute of Toxicology, School of Public Health, Cheeloo College of Medicine, Shandong University, 250012, Jining, Shandong, China;

关键词: Osteoporosis;    Chondroitin sulfate;    Intestinal flora;    Metabolomics;    Lipid metabolism;   

DOI  :  10.1186/s12986-023-00726-3

 received in 2022-10-29, accepted in 2023-01-21,  发布年份 2023

来源: Springer

【 摘 要 】

The use of non-drug intervention for calcium deficiency has attracted attention in recent years. Although calcium carbonate is the preferred raw material for calcium supplementation, there are few reports on the mechanism of the combined action of chondroitin sulfate and calcium to alleviate osteoporosis from the perspective of gut microbiota and metabolomics. In this study, a rat model of osteoporosis was established by feeding a low-calcium diet. The intestinal microbiota abundance, fecal and plasma metabolite expression levels of rats fed a basal diet, a low-calcium diet, a low-calcium diet plus calcium carbonate, and a low-calcium diet plus chondroitin sulfate were compared. The results showed that compared with the low calcium group, the calcium content and bone mineral density of femur were significantly increased in the calcium carbonate and chondroitin sulfate groups. 16 S rRNA sequencing and metabolomics analysis showed that chondroitin sulfate intervention could reduce short-chain fatty acid synthesis of intestinal flora, slow down inflammatory response, inhibit osteoclast differentiation, promote calcium absorption and antioxidant mechanism, and alleviate osteoporosis in low-calcium feeding rats. Correlation analysis showed that the selected intestinal flora was significantly correlated with metabolites enriched in feces and plasma. This study provides scientific evidence of the potential impact of chondroitin sulfate as a dietary supplement for patients with osteoporosis.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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