Skull metastasis is a poor prognostic factor for prostate cancer patients with bone metastasis: a retrospective study based on a Chinese population

BMC Urology

Research

Minfu Yang¹  Yun Cui²  Fang Cao²  Xiaobo Ye²  Tianyu Xiong²  Mingxin Jiang³  Guangyi Zhu³  Yinong Niu³ 

[1]Department of Nuclear Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

[2]Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

[3]Department of Urology, Beijing Shijitan Hospital, Capital Medical University, 10 Tieyiyuan Road, Haidian District, Beijing, China

关键词: Skull metastasis;    Prostate cancer;    Bone metastasis;    Prognosis;    Castration-resistant prostate cancer;   

DOI  :  10.1186/s12894-023-01179-9

 received in 2022-10-12, accepted in 2023-01-25,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundSkull is a relatively rare metastasis site for prostate cancer (PCa). There is no evidence regarding the prognostic indication of skull metastasis (SM) in PCa patients. In this study, we analyzed the prognostic value of SM for metastatic PCa patients receiving androgen deprivation therapy (ADT).Methods107 consecutive patients were included from September 2008 to August 2021. All patients were administered with standard ADT. Abiraterone plus glucocorticoid and/or docetaxel chemotherapy were given after failure to castration-resistant prostate cancer. Clinical parameters and follow-up prognostic data were retrospectively analyzed. The association of clinical and pathological parameters with SM were analyzed. The progression-free survival (PFS) and overall survival (OS) were assessed using Kaplan–Meier analysis and Cox regression analyses.ResultsPatients with SM (n = 26) had significantly higher biopsy Gleason scores, higher clinical T stage, higher prostate-specific antigen level at diagnosis, and were more likely to have high-burden metastasis and lymph node metastasis, compared with those without SM (n = 81). They also showed significantly lower level of hemoglobin, albumin and serum calcium, along with higher level of alkaline phosphatase. SM was significantly associated with shorter medium PFS (9.4 vs. 18.3 months, p < 0.001) and OS (22.2 vs. 58.2 months, p < 0.001). Cox analysis demonstrated that SM was an independent risk factor for shorter PFS (hazard ratio 2.327 [1.429–3.789], p = 0.001) and shorter OS (hazard ratio 2.810 [1.615–4.899], p < 0.001).ConclusionIn this study, we found that SM was significantly correlated with more aggressive disease and indicated poor prognosis in PCa patients with bone metastasis. Our study may provide useful reference for the risk stratification of PCa patients.

【 授权许可】

CC BY   
© The Author(s) 2023

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