Epidemiological and clinical characteristics of children with confirmed COVID-19 infection in a tertiary referral hospital in Manila, Philippines

Tropical Medicine and Health

Short Report

Jay Ron Padua¹  Grace Devota Go¹  Ana Ria Sayo¹  Kristal An Agrupis²  Greco Mark Malijan²  Rhanee Lota-Salvado³  Chris Smith⁴  Shuichi Suzuki⁵ 

[1] San Lazaro Hospital, Manila, Philippines;San Lazaro Hospital–Nagasaki University Collaborative Research Office, Manila, Philippines;School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan;School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan;Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK;School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan;San Lazaro Hospital–Nagasaki University Collaborative Research Office, Manila, Philippines;

关键词: COVID-19;    Epidemiology;    Philippines;    Children;    Pediatric;    Low- and middle-income countries (LMIC);   

DOI  :  10.1186/s41182-023-00507-x

 received in 2023-01-25, accepted in 2023-02-18,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundCOVID-19 has challenged the under-resourced health systems of low- and middle-income countries, significantly affecting child health. Available published data on Filipino children with COVID-19 infection are limited. This study aims to describe the epidemiological and clinical characteristics of pediatric patients with confirmed COVID-19 in an infectious disease hospital in Manila, Philippines.Main textThis cross-sectional study reviewed data on patients ages 0 to 18 years with confirmed COVID-19 infection, admitted to San Lazaro Hospital from January 25, 2020 to January 25, 2022. Demographic data and clinical characteristics obtained from COVID-19 case investigation forms were summarized and compared between severe and non-severe cases. Risk factors for disease severity and mortality were analyzed. Of 115 patients, 64% were males. There were 87 patients (75.7%) with asymptomatic, mild, or moderate disease, and 28 cases (24.3%) with severe or critical illness. The median age of all patients was 10 years (interquartile range: 4–15 years). The majority of patients (40.9%) were adolescents ages 13 to 18 years. Predominant symptoms were fever (73.9%) and cough (55.7%). Patients with severe or critical illness were more likely to experience difficulty of breathing (55.2% vs 44.8%, p < 0.001), and have a longer hospital stay (11 days vs 8 days, p = 0.043). Among all patients, 48.7% had at least one underlying disease; and common infectious co-morbidities were tuberculosis (17.4%), dengue (12.2%), and HIV (4.3%). Having tuberculosis (p = 0.008) or at least one co-morbidity (p < 0.001) was associated with disease severity. Ten patients (8.7%) died; and mortality was higher among those with severe or critical illness (80% vs 20%, p < 0.001). Sepsis (p = 0.020) or having at least one co-morbidity (p = 0.007) was associated with death.ConclusionChildren of all ages remain susceptible to COVID-19 infection, and usually present with mild or moderate symptoms. In this study, many adolescents are affected, highlighting the value of COVID-19 vaccination in this age group. Understanding the clinical features of COVID-19 in Filipino children is essential to identifying and optimally managing those at highest risk of severe disease.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 5