Epidemiological and clinical characteristics of the first 500 confirmed COVID-19 inpatients in a tertiary infectious disease referral hospital in Manila, Philippines

Tropical Medicine and Health

Koya Ariyoshi¹  Kelly Anne Estrada²  Rontgene Solante²  Ann Celestyn Uichanco²  Elizabeth Freda Telan²  Jose Benito Villarama²  Dorcas Umipig²  Efren Dimaano²  Jocelyn Sagurit²  Zita dela Merced²  Fe Villarama²  Edmundo Lopez²  Ana Ria Sayo²  Joy Calayo²  Chris Smith³  Annavi Marie Villanueva⁴  Kristal An Agrupis⁵  Shuichi Suzuki⁵ 

[1] Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan;San Lazaro Hospital, Manila, Philippines;School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan;Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK;School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan;San Lazaro Hospital, Manila, Philippines;School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan;San Lazaro Hospital–Nagasaki University Collaborative Research Office, Manila, Philippines;

关键词: COVID-19;    Philippines;    Epidemiology;    Low-resource setting;    Healthcare workers;    Mortality;   

DOI  :  10.1186/s41182-021-00340-0

来源: Springer

【 摘 要 】

BackgroundThe Philippines has been one of the most affected COVID-19 countries in the Western Pacific region, but there are limited data on COVID-19-related mortality and associated factors from this setting. We aimed to describe the epidemiological and clinical characteristics and associations with mortality among COVID-19-confirmed individuals admitted to an infectious diseases referral hospital in Metro Manila.Main textThis was a single-centre retrospective analysis including the first 500 laboratory-confirmed COVID-19 individuals admitted to San Lazaro Hospital, Metro Manila, Philippines, from January to October 2020. We extracted clinical data and examined epidemiological and clinical characteristics and factors associated with in-hospital mortality. Of the 500 individuals, 133 (26.6%) were healthcare workers (HCW) and 367 (73.4%) were non-HCW, with HCW more likely presenting with milder symptoms. Non-HCW admissions were more likely to have at least one underlying disease (51.6% vs. 40.0%; p = 0.002), with hypertension (35.4%), diabetes (17.4%), and tuberculosis (8.2%) being the most common. Sixty-one (12.2%) died, comprising 1 HCW and 60 non-HCW (0.7% vs. 16.3%; p < 0.001). Among the non-HCW, no death occurred for the 0–10 years age group, but deaths were recorded across all other age groups. Compared to those who recovered, individuals who died were more likely to be older (p < 0.001), male (p = 0.015), report difficulty of breathing (p < 0.001), be HIV positive (p = 0.008), be intubated (p < 0.001), categorised as severe or critical (p < 0.001), have a shorter mean hospital stay (p < 0.001), or have an additional diagnosis of pneumonia (p < 0.001) or ARDS (p < 0.001).ConclusionOur analysis reflected significant differences in characteristics, symptomatology, and outcomes between healthcare and non-healthcare workers. Despite the unique mix of cohorts, our results support the country’s national guideline on COVID-19 vaccination which prioritises healthcare workers, the elderly, and people with comorbidities and immunodeficiency states.

【 授权许可】

CC BY