Insights into organoid-based modeling of COVID-19 pathology

Virology Journal

Review

Tariq Al Jabry¹  Halima Albalushi²  Mohadese Hashem Boroojerdi²  Seyed Mohamad Javad Mirarefin³ 

[1] Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman;Department of Human and Clinical Anatomy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman;Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran;

关键词: COVID-19;    SARS-CoV-2;    Organoid;    Stem cell;    Regenerative medicine;   

DOI  :  10.1186/s12985-023-01996-2

 received in 2022-08-07, accepted in 2023-02-20,  发布年份 2023

来源: Springer

【 摘 要 】

Since December 2019, various types of strategies have been applied due to the emergent need to investigate the biology and pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to discover a functional treatment. Different disease modeling systems, such as mini-organ technology, have been used to improve our understanding of SARS-CoV-2 physiology and pathology. During the past 2 years, regenerative medicine research has shown the supportive role of organoid modeling in controlling coronavirus disease 2019 (COVID-19) through optimal drug and therapeutic approach improvement. Here, we overview some efforts that have been made to study SARS-CoV-2 by mimicking COVID-19 using stem cells. In addition, we summarize a perspective of drug development in COVID-19 treatment via organoid-based studies.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 3