Intraoperative hepatic subcapsular spider-like telangiectasia sign for the definitive diagnosis of biliary atresia

BMC Pediatrics

Research

Yan Tang¹  Zhu Jin²  Chengyan Tang²  Yuanmei Liu²  Kaizhi Zhang²  Zebing Zheng²  Rui Liu² 

[1] Clinical Medical College, Chengdu University, 610081, Chengdu, China;Department of Pediatric Surgery, Affiliated Hospital of Zunyi Medical University, 563000, Zunyi, China;Department of Pediatric Surgery, Guizhou Children’s Hospital, 563000, Zunyi, China;

关键词: Biliary atresia;    Hepatic subcapsular spider-like telangiectasia sign;    Ultrasonic examination;    Liver stiffness value;    Diagnosis;   

DOI  :  10.1186/s12887-022-03831-z

 received in 2022-06-29, accepted in 2022-12-29,  发布年份 2022

来源: Springer

【 摘 要 】

ObjectiveTo evaluate the accuracy of intraoperative hepatic subcapsular spider-like telangiectasia (HSST) sign for differentiating biliary atresia (BA) from other causes of hepatic cholestasis.MethodsThe data of 69 patients with jaundice treated from January 2019 to December 2021 were retrospectively analyzed. Based on intraoperative cholangiography (IOC), the patients were divided into two groups: the BA group (n = 49) and the non-BA group (n = 20). The biochemistry tests, liver ultrasound, liver stiffness value and HSST sign of the two groups were compared.ResultsThe incidence of abnormal gallbladder, elevated γ-glutamyl transpeptidase (γ-GGT) > 182.0U/L and abnormal liver stiffness (> 6.4 kPa) in BA group were significantly higher than those in non-BA group (P < 0.001). The HSST sign was present in all BA patients and not found in non-BA group. The area under receiver operating curve of direct bilirubin(DBIL), γ-GGT, abnormal gallbladder, liver stiffness value and HSST sign were 0.53, 0.84, 0.78, 0.96, and 1.00, respectively. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value(NPV) of HSST sign in the diagnosis of BA were all 100%.ConclusionPresence of HSST sign on diagnostic laparoscopy is highly suggestive of BA.It can be used in the differential diagnosis of BA and non-BA.Level of evidenceLevel III.

【 授权许可】

CC BY   
© The Author(s) 2023

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