The Michigan Genetic Hereditary Testing (MiGHT) study’s innovative approaches to promote uptake of clinical genetic testing among cancer patients: a study protocol for a 3-arm randomized controlled trial

Trials

Study Protocol

Erika N. Hanson¹  Elizabeth Bacon¹  Sarah Austin²  Elizabeth A. Rizzo²  Sarah T. Hawley²  Matthew Demerath²  Shayna Weiner²  Stefanie Goodall²  Erika Koeppe³  Elena M. Stoffel⁴  Wendy R. Uhlmann⁵  J. Scott Roberts⁶  Lynette Hammond Gerido⁶  Emerson Delacroix⁷  Kelley M. Kidwell⁸  Ken Resnicow⁸  Jennifer J. Griggs⁹ 

[1] Department of Internal Medicine, University of Michigan, Ann Arbor, USA;University of Michigan Rogel Cancer Center, Ann Arbor, USA;University of Michigan Rogel Cancer Center, Ann Arbor, USA;Department of Internal Medicine, University of Michigan, Ann Arbor, USA;University of Michigan Rogel Cancer Center, Ann Arbor, USA;University of Michigan School of Medicine, Ann Arbor, USA;Department of Internal Medicine, University of Michigan, Ann Arbor, USA;University of Michigan School of Medicine, Ann Arbor, USA;Department of Internal Medicine, University of Michigan, Ann Arbor, USA;University of Michigan School of Public Health, Ann Arbor, USA;University of Michigan School of Public Health, Ann Arbor, USA;Department of Internal Medicine, University of Michigan, Ann Arbor, USA;University of Michigan School of Public Health, Ann Arbor, USA;University of Michigan Rogel Cancer Center, Ann Arbor, USA;University of Michigan School of Public Health, Ann Arbor, USA;University of Michigan Rogel Cancer Center, Ann Arbor, USA;University of Michigan School of Medicine, Ann Arbor, USA;

关键词: RCT;    Genetic testing;    Genetic counseling;    Cancer;    Motivational interviewing;    eHealth;   

DOI  :  10.1186/s13063-023-07125-2

 received in 2022-12-05, accepted in 2023-01-28,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundAlthough most cancers are sporadic, germline genetic variants are implicated in 5–10% of cancer cases. Clinical genetic testing identifies pathogenic germline genetic variants for hereditary cancers. The Michigan Genetic Hereditary Testing (MiGHT) study is a three-arm randomized clinical trial that aims to test the efficacy of two patient-level behavioral interventions on uptake of cancer genetic testing.MethodsThe two interventions being tested are (1) a virtual genetics navigator and (2) motivational interviewing by genetic health coaches. Eligible participants are adults with a diagnosis of breast, prostate, endometrial, ovarian, colorectal, or pancreatic cancer who meet the National Comprehensive Cancer Network (NCCN) criteria for genetic testing. Participants are recruited through community oncology practices affiliated with the Michigan Oncology Quality Consortium (MOQC) and have used the Family Health History Tool (FHHT) to determine testing eligibility. The recruitment goal is 759 participants, who will be randomized to usual care or to either the virtual genetics navigator or the motivational interviewing intervention arms. The primary outcome will be the proportion of individuals who complete germline genetic testing within 6 months.DiscussionThis study addresses patient-level factors which are associated with the uptake of genetic testing. The study will test two different intervention approaches, both of which can help address the shortage of genetic counselors and improve access to care.Trial registrationThis study has been approved by the Institutional Review Board of the University of Michigan Medical School (HUM00192898) and registered in ClinicalTrials.gov (NCT05162846).

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 2