Evaluation of the immune response of dogs after a mass vaccination campaign against rabies in Tunisia

BMC Veterinary Research

Research

Jihen Bensalem¹  Samia BenMaiz¹  Farah Bassalah¹  Mariem Handous¹  Nourhene Basdouri¹  Mohamed Soltani¹  Habib Kharmachi¹  Imed Turki²  Abdejelil Ghram³ 

[1] University of Tunis El Manar, Rabies Laboratory, Institut Pasteur of Tunis, Tunis, Tunisia;University of Tunis El Manar, Rabies Laboratory, Institut Pasteur of Tunis, Tunis, Tunisia;Contagious Diseases, Zoonoses and Health Legislation Department, University of Manouba, National School of Veterinary Medicine, Sidi Thabet, Tunisia;University of Tunis El Manar, Rabies Laboratory, Institut Pasteur of Tunis, Tunis, Tunisia;University of Tunis El Manar, Laboratory of Epidemiology and Veterinary Microbiology, Institut Pasteur of Tunis, Tunis, Tunisia;

关键词: Rabies virus;    Dogs;    Immune response;    FAVN;   

DOI  :  10.1186/s12917-023-03582-8

 received in 2021-12-23, accepted in 2023-01-19,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundRabies (RABV) is an enzootic disease in Tunisia, with dogs being the primary reservoir. Vaccinating dogs is the key to eradicate rabies. Regional Veterinary Services conduct nationwide immunisation campaigns on an annual basis. Evaluation of the immune response is still important to make sure that the vaccination is effective in the conditions of the Tunisian field. In this paper, the FAVN technique was used to test rabies antibody dynamics in dogs from three distinct Tunisian areas observed for one year following a mass vaccination campaign.ResultsOn day 30 after vaccination, 75% of all dogs vaccinated during the campaign were sero-positive (titres greater than or equal to 0.5 transformed IU/ml). On day 180, 48% of all dogs were sero-positive. Only 25.6% of primary-vaccinated dogs remained sero-positive on day 180 and 7% on day 365, whereas 91% of previously sero-positive dogs remained sero-positive on day 365.ConclusionsAlthough a single rabies vaccine is successful at stimulating an immunological response, it is recommended that primary-vaccinated dogs have a second booster between one and three months after the initial vaccination to maintain seropositivity. To achieve the rabies eradication objective, all dogs should receive an annual booster to maintain effective immunological protection.

【 授权许可】

CC BY   
© The Author(s) 2023

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