Development of SARS-CoV-2 specific IgG and IgA antibodies in serum and milk with different SARS-COV-2 vaccines in lactating women

International Breastfeeding Journal

Research

Javier Llorca¹  Inés Gómez-Acebo²  Carolina Lechosa-Muñiz³  María Paz-Zulueta⁴  Juan Irure-Ventura⁵  Marcos López-Hoyos⁶  Jose Manuel Mendez-Legaza⁷  Rocío CuestaGonzález⁸  María Jesús Cabero-Pérez⁹ 

[1] Departamento de Ciencias Médicas y Quirúrgicas. Universidad de Cantabria, Santander, Spain;CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain;Departamento de Ciencias Médicas y Quirúrgicas. Universidad de Cantabria, Santander, Spain;IDIVAL, Cantabria, Spain;CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain;Departamento de Enfermería, Universidad de Cantabria, Santander, Spain;Breastfeeding Coordinator, IBCLC, Hospital Universitario Marqués de Valdecilla, Cantabria, Spain;Departamento de Enfermería, Universidad de Cantabria, Santander, Spain;IDIVAL- Grupo de Investigación en Derecho Sanitario y Bioética, GRIDES, Cantabria, Spain;Department of Immunology, Hospital Universitario Marqués de Valdecilla, Santander, Spain;Department of Immunology, Hospital Universitario Marqués de Valdecilla, Santander, Spain;IDIVAL, Cantabria, Spain;Laboratory, Molecular Biology Department, University of Cantabria, Santander, Spain;Department of Microbiology, Hospital Universitario Marqués de Valdecilla, Cantabria, Spain;Department of Pediatrics, Hospital Universitario Marqués de Valdecilla, Cantabria, Spain;Department of Pediatrics, Hospital Universitario Marqués de Valdecilla, Cantabria, Spain;Departamento de Ciencias Médicas y Quirúrgicas. Universidad de Cantabria, Santander, Spain;IDIVAL, Cantabria, Spain;Red de Salud Materno Infantil y del Desarrollo – SAMID. Instituto de Salud Carlos III, Madrid, Spain;

关键词: Adverse effects;    SARS-COV-2 vaccine;    Breastfeeding;    Breast milk;    Maternal immunity;    Neonatal immunity;    Antibodies;   

DOI  :  10.1186/s13006-022-00536-y

 received in 2022-04-13, accepted in 2022-12-18,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundOur main objective was to determine the evolution of IgG and IgA antibodies directed against SARS-CoV-2 protein S in the blood of lactating women and in breast milk.MethodsA cohort of 110 uninfected and vaccinated breastfeeding women was followed-up for 6 months at the Marqués de Valdecilla University Hospital, Spain, in 2020. An additional group of 23 breastfeeding mothers who had no previously documented infection and had not been vaccinated against SARS-CoV-2 were included as a control group. The antibodies in blood and breast milk and their evolution at 6 months post-vaccination were analysed.ResultsOne hundred ten breastfeeding mothers were included; 70 women (63.6%) were vaccinated with two doses of BNT162b2, 20 women (18.2%) received two doses of mRNA-1273, and 20 women (18.2%) received a single dose of ChAdOx1-S. No evidence of differences between concentrations of antibodies was found according to the type of vaccine, with the exception of serum IgA antibodies, which was higher in women vaccinated with mRNA-1273: mean [95%CI]: 0.05 AU/mL [0.03,0.06] with mRNA-1273, 0.02 AU/mL [0.01,0.03] with BNT162b2 and 0.01 AU/mL [0.00,0.03] with ChAdOx1-S, ANOVA p value = 0.03. The lack of difference between vaccines was also found when anti-S1 specific IgG in serum and breast milk were measured.ConclusionsIn lactating women vaccinated against COVID-19, anti-SARS-CoV-2 antibodies can be detected in both serum and breastmilk 6 months after receiving the second dose, although their concentrations decreased when compared with concentrations reached immediately after vaccination.

【 授权许可】

CC BY   
© The Author(s) 2023

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