Activity-to-sedentary ratio provides novel insight into mortality reduction among male survivors of cardiovascular disease in the United States: national health and nutrition examination survey, 2007–2014

BMC Public Health

Research

Xiaoyan Zhu¹  Hongqin Zhao²  Mengying Niu²  Xudong Pan²  Qi Xiao²  Yuanyuan Ding²  Jiahao Chen³ 

[1] Department of Critical Care Medicine, The Affiliated Hospital of Qingdao University, 266000, Qingdao, Shandong, China;Department of Neurology, The Affiliated Hospital of Qingdao University, 266000, Qingdao, Shandong, China;State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China;Department of Epidemiology and Health Statistics, Public Health College, Qingdao University, Qingdao, China;

关键词: Activity-to-sedentary ratio;    Cardiovascular disease;    Mortality;    Males;    National Health and Nutrition Examination Survey;   

DOI  :  10.1186/s12889-023-14978-4

 received in 2022-10-17, accepted in 2023-01-02,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundLower physical activity and sedentary behavior have been identified as modifiable risk factors for cardiovascular disease (CVD). However, the quantitative, dose-response association between activity-to-sedentary ratio (ASR) and mortality is unknown.MethodsProspective cohort studies with participants 50 to 80 years that reported the association between recreational physical activity, sedentary behavior, and all-cause mortality were included from the 2007 to 2014 United States National Health and Nutrition Examination Survey (NHANES) and followed through December 31, 2015. Cox or Weibull regression models and restricted cubic splines were used to determine the association between ASR and all-cause mortality.ResultsSixty deaths occurred among 498 CVD survivors, with a median of 56 months of follow-up. After accounting for all covariates, CVD survivors with an ASR between 0.21 and 0.57 (hazard ratio [HR], 0.47; 95% confidence interval [CI], 0.25–0.87) and those with an ASR more than 0.57 (HR, 0.40; 95% CI, 0.20–0.81) were at significantly lower risk for mortality than participants with an ASR <  0.21. Moreover, a nonlinear negative association and an L-shaped association were observed for the level of ASR with risk of mortality among CVD survivors (P for nonlinearity = 0.004). What’s more, adjusting for covariates, a statistically significant interaction (P for interaction = 0.016) between sex and ASR, an increase of ASR more than and equal to 0.18 was associated with a lower risk of mortality among males (HR, 0.23; 95% CI, 0.12–0.46).ConclusionsAn negative correlation between ASR and mortality in CVD survivors, especially in males when ASR is more than 0.18. Our novel findings provide further insights into easing the global burden of deaths.

【 授权许可】

CC BY   
© The Author(s) 2023

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