Polypharmacy and potentially inappropriate medications among hospitalized older adults with COVID-19 in Malaysian tertiary hospitals

Journal of Pharmaceutical Policy and Practice

Short Report

Philip Rajan¹  Chee-Tao Chang²  Hoo Seng Tan³  James Yau Hon Voo³  Peng Seng Ong⁴  Jie Min Lee⁴  Yuet Man Low⁵  Doris George⁵  Wei Mun Liew⁵  Siti Fatimah Kamis⁶  Aie Yen Tan⁶  Chun Kiat Lim⁷  Nasiha Sufina Ramzuzzaman⁷  Siti Mallissa Mohd Shariff⁷  Nur Suriana Abu Bakar⁷  Eddy Yew Joe Lim⁷  Shaun Wen Huey Lee⁸ 

[1] Clinical Research Centre (CRC) HRPB Ipoh, Hospital Raja Permaisuri Bainun, Ministry of Health Malaysia, Ipoh, Malaysia;School of Medicine, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya, Malaysia;Clinical Research Centre (CRC) HRPB Ipoh, Hospital Raja Permaisuri Bainun, Ministry of Health Malaysia, Ipoh, Malaysia;School of Pharmacy, Monash University Malaysia, Subang Jaya, Malaysia;Pharmacy Department, Hospital Duchess of Kent, Ministry of Health Malaysia, Sandakan, Malaysia;Pharmacy Department, Hospital Pulau Pinang, Ministry of Health Malaysia, George Town, Malaysia;Pharmacy Department, Hospital Raja Permaisuri Bainun, Ministry of Health Malaysia, Ipoh, Malaysia;Pharmacy Department, Hospital Sultan Ismail, Ministry of Health Malaysia, Johor Bahru, Malaysia;Pharmacy Department, Hospital Sungai Buloh, Ministry of Health Malaysia, Sungai Buloh, Malaysia;School of Pharmacy, Monash University Malaysia, Subang Jaya, Malaysia;

关键词: Polypharmacy;    Potentially inappropriate medications;    Hospital;    Older adults;    COVID-19;    Malaysia;   

DOI  :  10.1186/s40545-022-00504-1

 received in 2022-11-21, accepted in 2022-12-11,  发布年份 2022

来源: Springer

【 摘 要 】

IntroductionOlder adults are among the most vulnerable groups during the COVID-19 epidemic, contributing to a large proportion of COVID-19-related death. Medication review and reconciliation by pharmacist can help reduce the number of potentially inappropriate medications but these services were halted during COVID-19.AimTo assess the prevalence and factors associated with inappropriate medicine use among older populations with COVID-19.MethodsThis was a cross-sectional, retrospective analysis of medications among hospitalized older adults with COVID-19. Potentially inappropriate medication use was categorized using the Beer’s and STOPP criteria.ResultsCombining both criteria, 181 (32.7%) of the 553 patients were identified to have used at least one or more potentially inappropriate medication. A marginally higher number of inappropriate medications was documented using the Beers 2019 criteria (151 PIM in 124 patients) compared to STOPP criteria (133 PIMS in 104 patients). The long-term use of proton pump inhibitors (n = 68; 12.3%) and drugs which increases the risk of postural hypotension were the most commonly reported PIM (n = 41; 7.4%). Potentially inappropriate medication use was associated with previous history of hospital admission in the past 12 months (Odds ratio [OR]: 2.27; 95% CI 1.29–3.99) and higher number of discharge medications.ConclusionsNearly, one in three older adults with COVID-19 had been prescribed a PIM, and the proportion of older adults with polypharmacy increased after discharge. This highlights the importance of having clinical pharmacist conducting medication reviews to identify PIMs and ensure medication appropriateness.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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