Polypharmacy and potentially inappropriate medications among hospitalized older adults with COVID-19 in Malaysian tertiary hospitals

Southern Med Review

article

Chang, Chee-Tao¹  Mohd Shariff, Siti Mallissa³  Abu Bakar, Nur Suriana³  Ramzuzzaman, Nasiha Sufina³  Lim, Chun Kiat³  Lim, Eddy Yew Joe³  Ong, Peng Seng⁴  Lee, Jie Min⁴  Tan, Aie Yen⁵  Kamis, Siti Fatimah⁵  Liew, Wei Mun⁶  Low, Yuet Man⁶  George, Doris⁶  Voo, James Yau Hon⁷  Tan, Hoo Seng⁷  Rajan, Philip¹  Lee, Shaun Wen Huey² 

[1] Clinical Research Centre ,(CRC) HRPB Ipoh, Hospital Raja Permaisuri Bainun, Ministry of Health Malaysia;School of Pharmacy, Monash University Malaysia;Pharmacy Department, Hospital Sungai Buloh, Ministry of Health Malaysia;Pharmacy Department, Hospital Pulau Pinang, Ministry of Health Malaysia;Pharmacy Department, Hospital Sultan Ismail, Ministry of Health Malaysia;Pharmacy Department, Hospital Raja Permaisuri Bainun, Ministry of Health Malaysia;Pharmacy Department, Hospital Duchess of Kent, Ministry of Health Malaysia;School of Medicine, Faculty of Health and Medical Sciences, Taylor’s University

关键词: Polypharmacy;    Potentially inappropriate medications;    Hospital;    Older adults;    COVID-19;    Malaysia;   

DOI  :  10.1186/s40545-022-00504-1

学科分类：药理学

来源: BioMed Central

【 摘 要 】

Older adults are among the most vulnerable groups during the COVID-19 epidemic, contributing to a large proportion of COVID-19-related death. Medication review and reconciliation by pharmacist can help reduce the number of potentially inappropriate medications but these services were halted during COVID-19. To assess the prevalence and factors associated with inappropriate medicine use among older populations with COVID-19. This was a cross-sectional, retrospective analysis of medications among hospitalized older adults with COVID-19. Potentially inappropriate medication use was categorized using the Beer’s and STOPP criteria. Combining both criteria, 181 (32.7%) of the 553 patients were identified to have used at least one or more potentially inappropriate medication. A marginally higher number of inappropriate medications was documented using the Beers 2019 criteria (151 PIM in 124 patients) compared to STOPP criteria (133 PIMS in 104 patients). The long-term use of proton pump inhibitors (n = 68; 12.3%) and drugs which increases the risk of postural hypotension were the most commonly reported PIM (n = 41; 7.4%). Potentially inappropriate medication use was associated with previous history of hospital admission in the past 12 months (Odds ratio [OR]: 2.27; 95% CI 1.29–3.99) and higher number of discharge medications. Nearly, one in three older adults with COVID-19 had been prescribed a PIM, and the proportion of older adults with polypharmacy increased after discharge. This highlights the importance of having clinical pharmacist conducting medication reviews to identify PIMs and ensure medication appropriateness.

【 授权许可】

Unknown