Adhesive hydrogels in osteoarthritis: from design to application

Military Medical Research

Review

Fei Yang¹  Raghvendra Bohara²  Sergio Martin-Saldaña²  Abhay Pandit²  Yong Xie³  Yi-Yang Zhao⁴  Li-Ning Zhang⁴  Wang-Lin Duan⁵  Ya-Zhong Bu⁵ 

[1] Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, 100190, Beijing, China;School of Chemical Sciences, University of Chinese Academy of Sciences, 100049, Beijing, China;CÚRAM, SFI Research Centre for Medical Devices, University of Galway, H91 TK33, Galway, Ireland;Department of Orthopedics, the Fourth Medical Center, Chinese PLA General Hospital, 100853, Beijing, China;National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation, 100853, Beijing, China;Department of Rehabilitation Medicine, the First Medical Center, Chinese PLA General Hospital, No.28 Fuxing Road, Haidian District, 100853, Beijing, China;Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, 710061, Xi’an, China;

关键词: Adhesive hydrogel;    Osteoarthritis (OA);    Functional additives;    Cartilage regeneration;    Interdisciplinary therapy;   

DOI  :  10.1186/s40779-022-00439-3

 received in 2022-08-02, accepted in 2022-12-31,  发布年份 2022

来源: Springer

【 摘 要 】

Osteoarthritis (OA) is the most common type of degenerative joint disease which affects 7% of the global population and more than 500 million people worldwide. One research frontier is the development of hydrogels for OA treatment, which operate either as functional scaffolds of tissue engineering or as delivery vehicles of functional additives. Both approaches address the big challenge: establishing stable integration of such delivery systems or implants. Adhesive hydrogels provide possible solutions to this challenge. However, few studies have described the current advances in using adhesive hydrogel for OA treatment. This review summarizes the commonly used hydrogels with their adhesion mechanisms and components. Additionally, recognizing that OA is a complex disease involving different biological mechanisms, the bioactive therapeutic strategies are also presented. By presenting the adhesive hydrogels in an interdisciplinary way, including both the fields of chemistry and biology, this review will attempt to provide a comprehensive insight for designing novel bioadhesive systems for OA therapy.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

41116_2022_35_Article_IEq457.gif

41116_2022_35_Article_IEq448.gif

41116_2022_35_Article_IEq435.gif