Injectable Self-Healing Adhesive pH-Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing

Nano-Micro Letters

Jipeng Li¹  Dake Chu²  Yutong Yang²  Baolin Guo³  Jiahui He³  Zixi Zhang⁴  Shaojun Zhu⁵  Gang He⁶  Fenggang Ren⁷  Rongqian Wu⁷  Yi Lv⁷  Feng Ma⁷ 

[1] Department of Experimental Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, People’s Republic of China;Department of Gastroenterology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China;Department of Gastroenterology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China;Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University, 710049, Xi’an, China;Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, 710049, Xi’an, People’s Republic of China;Department of Gastroenterology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China;Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University, 710049, Xi’an, China;Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, 710049, Xi’an, People’s Republic of China;Department of Dermatology, The First Affiliated Hospital of Xi’an Jiaotong University, 710049, Xi’an, People’s Republic of China;Department of Pathology, Tangdu Hospital, Fourth Military Medical University, Xi’an, People’s Republic of China;Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University, 710049, Xi’an, China;Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, 710049, Xi’an, People’s Republic of China;National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine and Surgical Engineering Research Center of Shaanxi Province, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China;

关键词: Injectable self-healing hydrogel;    Adhesive hydrogel;    Gastric hemostasis;    Gastric wound healing;    Endoscopic treatment;   

DOI  :  10.1007/s40820-020-00585-0

来源: Springer

【 摘 要 】

tsA series of novel injectable pH-responsive self-healing hydrogels with enhanced adhesive strength were prepared.The hydrogels showed good gastric hemostasis property in a swine gastric hemorrhage model.The hydrogels greatly enhanced gastric wound healing in a swine gastric wound model.

【 授权许可】

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