Nationwide genomic surveillance reveals the prevalence and evolution of honeybee viruses in China

Microbiome

Research

Weipeng Kang¹  Jiangli Wu¹  Shufa Xu¹  Nannan Li¹  Tao Hu²  Weifeng Shi³  Hong Zhou⁴  Cixiu Li⁴  Juan Li⁴  Jingkai Ji⁴  Edward C. Holmes⁵ 

[1] Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, 100193, Beijing, China;Key Laboratory of Emerging Infectious Diseases in Universities of Shandong, Department of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, 271000, Taian, China;Key Laboratory of Emerging Infectious Diseases in Universities of Shandong, Department of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, 271000, Taian, China;School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, 271000, Taian, China;Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China;Key Laboratory of Emerging Infectious Diseases in Universities of Shandong, Department of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, 271000, Taian, China;Sydeny Institute for Infectious Diseases, School of Medical Sciences, The University of Sydney, 2006, Sydney, NSW, Australia;

关键词: Honeybees;    Ectoparasite mites;    Meta-transcriptomics;    Virus landscape;    Evolution;    Virus discovery;   

DOI  :  10.1186/s40168-022-01446-1

 received in 2022-05-19, accepted in 2022-12-08,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundThe economic and environmental value of honeybees has been severely challenged in recent years by the collapse of their colonies worldwide, often caused by outbreaks of infectious diseases. However, our understanding of the diversity, prevalence, and transmission of honeybee viruses is largely obscure due to a lack of large-scale and longitudinal genomic surveillance on a global scale.ResultsWe report the meta-transcriptomic sequencing of nearly 2000 samples of the two most important economic and widely maintained honeybee species, as well as an associated ectoparasite mite, collected across China during 2016–2019. We document the natural diversity and evolution of honeybee viruses in China, providing evidence that multiple viruses commonly co-circulate within individual bee colonies. We also expanded the genomic data for 12 important honeybee viruses and revealed novel genetic variants and lineages associated with China. We identified more than 23 novel viruses from the honeybee and mite viromes, with some exhibiting ongoing replication in their respective hosts. Together, these data provide additional support to the idea that mites are an important reservoir and spill-over host for honeybee viruses.ConclusionsOur data show that honeybee viruses are more widespread, prevalent, and genetically diverse than previously realized. The information provided is important in mitigating viral infectious diseases in honeybees, in turn helping to maintain sustainable productive agriculture on a global scale.9bxHgmASzr9JN-8jG-Ub-NVideo Abstract

【 授权许可】

CC BY   
© The Author(s) 2023

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