Retrospective meta-transcriptomic identification of severe dengue in a traveller returning from Africa to Sweden, 1990

One Health

John H.-O. Pettersson¹  David Ekqvist²  Kristian Alfsnes³  Jon Bohlin³  Edward C. Holmes⁴  Nina Lagerqvist⁵  Sirkka Vene⁵  Jenny Verner-Carlsson⁵  Andreas Bråve⁵  Weifeng Shi⁶ 

[1] Shandong Academy of Medical Sciences, Taian 271016, China;Department of Infectious Diseases, University Hospital Linköping, Sweden;Infectious Disease Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway;Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, the University of Sydney, Sydney, New South Wales 2006, Australia;Public Health Agency of Sweden, Nobels väg 18, SE-171 82 Solna, Sweden;;School of Public Health, Shandong First Medical University &

关键词: Dengue virus;    Dengue haemorrhagic fever;    Viral haemorrhagic fever;    Meta-transcriptomics;    RNA-sequencing;    Human pegivirus;   

DOI  :  

来源: DOAJ

【 摘 要 】

Pathogens associated with haemorrhagic fever commonly have zoonotic origins. The first documented imported case of likely viral severe haemorrhagic fever in Sweden occurred in 1990. Despite extensive study, no aetiological agent was identified. Following retrospective investigation with total RNA-sequencing of samples collected between 7 and 36 days from onset of symptoms we identified dengue virus 3 (DENV-3) and a human pegivirus (HPgV). We conclude that the patient likely suffered from haemorrhagic symptoms due to an atypical severe and undiagnosed dengue infection.

【 授权许可】

Unknown