Semen quality changes during infection and recovery phases of mild-to-moderate COVID-19 in reproductive-aged patients: a prospective case series

Basic and Clinical Andrology

Research Article

Mohammed Ali Zarzour¹  Adel Kurkar¹  Nasreldin Mohammed¹  Mostafa Kamel¹  Hosny Behnsawy¹  Rabea Ahmed Gadelkareem¹  Ahmed Mohammed Abdel-Moniem¹ 

[1] Assiut Urology and Nephrology Hospital, Faculty of Medicine, Assiut University, Elgamaa Street, Assiut, Egypt;

关键词: COVID-19;    Fertility;    Semen analysis;    Spermatozoa;    Testis;    COVID-19;    Fertilité;    Analyse du Sperme;    Spermatozoïdes;    Testicule;   

DOI  :  10.1186/s12610-022-00175-7

 received in 2022-08-04, accepted in 2022-11-01,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundDespite the documented effects of the coronavirus disease 2019 (COVID-19) on spermatogenesis, the reversibility of these effects is uncertain. We aimed to assess the changes of sperm quality between the infection and recovery phases of COVID-19 in reproductive-aged men. The semen quality of men with mild-to-moderated COVID-19 (defined by the degrees of symptoms and chest involvement on computed tomography) was studied during October, 2020–May, 2021 at our hospital. Two semen samples were analyzed at timings estimated to represent spermatogenic cycles during the infection and recovery phases of COVID-19.ResultsA total of 100 patients were included with mean ± SD (range) age of 24.6 ± 3.3 (21–35) years. During infection, 33% of patients had abnormal semen quality. However, a significant reduction was found in this abnormality from 33 to 11% (P < 0.001) after recovery from infection. In a comparison of the two semen analyses, there were significant improvements in the mean values of sperm progressive motility (P =0.043) and normal morphology (P < 0.001). However, the mean sperm concentration showed a statistically insignificant increase (P = 0.844).ConclusionsIn reproductive-aged patients with mild-to-moderate COVID-19, the effects on seminal quality were recoverable, represented by significant improvements in the means of progressive sperm motility and normal morphology between the infection and recovery phases of COVID-19.Trial registrationClinicalTrials, NCT04595240.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

41116_2022_35_Article_IEq580.gif

41116_2022_35_Article_IEq579.gif

41116_2022_35_Article_IEq578.gif

41116_2022_35_Article_IEq574.gif