Impaired insulin-stimulated myocardial glucose metabolic rate is associated with reduced estimated myocardial energetic efficiency in subjects with different degrees of glucose tolerance

Cardiovascular Diabetology

Research

Giorgio Sesti¹  Francesco Cicone²  Giuseppe Lucio Cascini²  Annalisa Papa²  Teresa Vanessa Fiorentino³  Maria Perticone³  Patrizia Vizza³  Pietro Hiram Guzzi³  Pierangelo Veltri³  Sofia Miceli³  Angela Sciacqua⁴  Francesco Andreozzi⁴  Elena Succurro⁴ 

[1] Department of Clinical and Molecular Medicine, University of Rome-Sapienza, 00189, Rome, Italy;Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy;Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Viale Europa, 88100, Catanzaro, Italy;Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Viale Europa, 88100, Catanzaro, Italy;Research Center for the Prevention and Treatment of Metabolic Diseases (CR METDIS), University Magna Graecia of Catanzaro, Catanzaro, Italy;

关键词: Myocardial glucose metabolism;    Myocardial mechano-energetic efficiency;    Cardiovascular disease;    Insulin sensitivity;    Type 2 diabetes;    Prediabetes;    Cardiac F-FDG PET;    Cardiac workload;   

DOI  :  10.1186/s12933-022-01733-z

 received in 2022-09-27, accepted in 2022-12-28,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundAlterations in myocardial mechano-energetic efficiency (MEEi), which represents the capability of the left ventricles to convert the chemical energy obtained by oxidative metabolism into mechanical work, have been associated with cardiovascular disease. Although whole-body insulin resistance has been related to impaired myocardial MEEi, it is unknown the relationship between cardiac insulin resistance and MEEi. Aim of this study was to evaluate the relationship between insulin-stimulated myocardial glucose metabolic rate (MrGlu) and myocardial MEEi in subjects having different degrees of glucose tolerance.MethodsWe evaluated insulin-stimulated myocardial MrGlu using cardiac dynamic positron emission tomography (PET) with 18F-Fluorodeoxyglucose (18F-FDG) combined with euglycemic-hyperinsulinemic clamp, and myocardial MEEi in 57 individuals without history of coronary heart disease having different degrees of glucose tolerance. The subjects were stratified into tertiles according to their myocardial MrGlu values.ResultsAfter adjusting for age, gender and BMI, subjects in I tertile showed a decrease in myocardial MEEi (0.31 ± 0.05 vs 0.42 ± 0.14 ml/s*g, P = 0.02), and an increase in myocardial oxygen consumption (MVO2) (10,153 ± 1375 vs 7816 ± 1229 mmHg*bpm, P < 0.0001) as compared with subjects in III tertile. Univariate correlations showed that insulin-stimulated myocardial MrGlu was positively correlated with MEEi and whole-body glucose disposal, and negatively correlated with waist circumference, fasting plasma glucose, HbA1c and MVO2. In a multivariate regression analysis running a model including several CV risk factors, the only variable that remained significantly associated with MEEi was myocardial MrGlu (β 0.346; P = 0.01).ConclusionsThese data suggest that an impairment in insulin-stimulated myocardial glucose metabolism is an independent contributor of depressed myocardial MEEi in subjects without history of CHD.

【 授权许可】

CC BY   
© The Author(s) 2023

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