European Journal of Medical Research | |
Primary headache types in adult epilepsy patients | |
Research | |
Tamir Avidgor1  Sana Hannan1  Gerhard Luef2  Gerald Walser2  Carlo Lorenzen2  Manuela Kaml2  Iris Unterberger2  Vera Filippi3  Gregor Broessner3  Katharina Schiller4  Markus Rauchenzauner5  | |
[1] Analytical Neurophysiology Lab, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada;Department of Neurology, Epilepsy Unit, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria;Department of Neurology, Headache Outpatient Clinic, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria;Department of Pediatrics and Neonatology, Hospital Ostallgaeu, Kaufbeuren, Germany;Analytical Neurophysiology Lab, Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada;Department of Pediatrics, Medical University Innsbruck, Innsbruck, Austria;Department of Pediatrics and Neonatology, Hospital Ostallgaeu, Kaufbeuren, Germany;Department of Pediatrics, Medical University Innsbruck, Innsbruck, Austria; | |
关键词: Headache; Epilepsy; AED; Migraine; Tension-type headache; | |
DOI : 10.1186/s40001-023-01023-8 | |
received in 2022-05-06, accepted in 2022-07-29, 发布年份 2022 | |
来源: Springer | |
【 摘 要 】
BackgroundHeadache is among the most common comorbidities in epilepsy. This study examined the distribution of different primary headache disorders in a large cohort of patients with diagnosed epilepsy. Headache types were analysed with regard to gender, type of epilepsy and antiepileptic drugs (AEDs).MethodsIn this prospective single-centre study, 500 patients with epilepsy (250 female, mean age: 45.52 ± 17.26 years) were evaluated with regards to primary headache types using a validated German headache questionnaire categorizing for migraine (MIG), tension-type headache (TTH) or trigeminal autonomic cephalalgias (TAC), their combinations and unclassifiable headache. Data regarding type of epilepsy, seizure-associated headache, AED treatment and seizure freedom were collected.ResultsOf 500 patients with epilepsy, 163 (32.6%) patients (108 female and 55 male) reported suffering from headaches at least 1 day per month. MIG (without aura, with aura) and TTH were the most frequent headache type (MIG 33.1%, TTH 33.1%). Female epilepsy patients reported headaches significantly more often than male patients (x2 = 8.20, p = 0.0042). In contrast, the type of epilepsy did not significantly affect headache distribution. Of 163 patients with headache, 66 (40.5%) patients reported seizure-associated headache and AEDs were used by 157 patients. Of importance, patients with AED monotherapy suffered from MIG less often when compared to patients on polytherapy (x2 = 4.79, p = 0.028).ConclusionMIG and TTH are the most common headache types in epilepsy patients and headache is more frequent among female epilepsy patients. Monotherapy in AEDs might have a beneficial effect on the frequency of headache compared to polytherapy.
【 授权许可】
CC BY
© The Author(s) 2023
【 预 览 】
Files | Size | Format | View |
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RO202305116680470ZK.pdf | 825KB | download | |
MediaObjects/12888_2022_4495_MOESM1_ESM.docx | 54KB | Other | download |
MediaObjects/12888_2023_4564_MOESM1_ESM.docx | 18KB | Other | download |
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