The Journal of Headache and Pain | |
Ictal epileptic headache: an old story with courses and appeals | |
Review Article | |
Paolo Martelletti1  Andrea Negro2  Vincenzo Belcastro3  Pasquale Parisi4  Pasquale Striano5  | |
[1] Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Regional Referral Headache Centre, Sant’Andrea Hospital, Sapienza University, Rome, Italy;Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Regional Referral Headache Centre, Sant’Andrea Hospital, Sapienza University, Rome, Italy;Stroke and Neurovascular Regulation Lab, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA;Department of Neuroscience, Neurology Clinic, Sant’Anna Hospital, Como, Italy;NESMOS Department, Faculty of Medicine and Psychology, Child Neurology, Headache Paediatric Center, Paediatric Sleep Disorders, Chair of Paediatrics, Sapienza University, c/o Sant’Andrea Hospital, Via di Grottarossa, 1035-1039, Rome, Italy;Pediatric Neurology and Muscular Diseases Unit-DINOGMI-Department of Neurosciences, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, University of Genoa, G. Gaslini Institute, Genoa, Italy; | |
关键词: Cortical spreading depression; Headache; Migraine; Epilepsy; Ictal epileptic headache; | |
DOI : 10.1007/s10194-012-0485-y | |
received in 2012-07-06, accepted in 2012-09-13, 发布年份 2012 | |
来源: Springer | |
【 摘 要 】
The term “ictal epileptic headache” has been recently proposed to classify the clinical picture in which headache is the isolated ictal symptom of a seizure. There is emerging evidence from both basic and clinical neurosciences that cortical spreading depression and an epileptic focus may facilitate each other, although with a different degree of efficiency. This review address the long history which lead to the 'migralepsy' concept to the new emerging pathophysiological aspects, and clinical and electroencephalography evidences of ictal epileptic headache. Here, we review and discuss the common physiopathology mechanisms and the historical aspects underlying the link between headache and epilepsy. Either experimental or clinical measures are required to better understand this latter relationship: the development of animal models, molecular studies defining more precise genotype/phenotype correlations as well as multicenter clinical studies with revision of clinical criteria for headache-/epilepsy-related disorders represent the start of future research. Therefore, the definition of ictal epileptic headache should be used to classify the rare events in which headache is the only manifestation of a seizure. Finally, using our recently published criteria, we will be able to clarify if ictal epileptic headache represents an underestimated phenomenon or not.
【 授权许可】
CC BY
© The Author(s) 2012
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202310138363485ZK.pdf | 151KB | download |
【 参考文献 】
- [1]
- [2]
- [3]
- [4]
- [5]
- [6]
- [7]
- [8]
- [9]
- [10]
- [11]
- [12]
- [13]
- [14]
- [15]
- [16]
- [17]
- [18]
- [19]
- [20]
- [21]
- [22]
- [23]
- [24]
- [25]
- [26]
- [27]
- [28]
- [29]
- [30]
- [31]
- [32]
- [33]
- [34]
- [35]
- [36]
- [37]
- [38]
- [39]
- [40]
- [41]
- [42]
- [43]
- [44]
- [45]
- [46]
- [47]
- [48]
- [49]
- [50]
- [51]
- [52]
- [53]
- [54]
- [55]
- [56]
- [57]
- [58]
- [59]
- [60]
- [61]
- [62]
- [63]
- [64]
- [65]
- [66]
- [67]
- [68]
- [69]
- [70]