Dysfunction of the glutamatergic photoreceptor synapse in the P301S mouse model of tauopathy

Acta Neuropathologica Communications

Research

S. Krantic¹  S. Cadoni²  C. Joffrois²  Q. César²  M. Valet²  G. Labernede²  L. Arouche-Delaperche²  S. Picaud²  J. Dégardin²  C. Gabriel³  S. Girardon⁴ 

[1] INSERM UMRS 938, Centre de Recherche Saint Antoine, CRSA, Sorbonne Université, 184 Rue Faubourg St Antoine, 75012, Paris, France;INSERM, CNRS, Institut de La Vision, Sorbonne Université, 17 Rue Moreau, 75012, Paris, France;Institut de Recherches Internationales Servier, 50 Rue Carnot, 92284, Suresnes, France;Institut de Recherches Servier, 125 Chemin de Ronde, 78290, Croissy-Sur-Seine, France;

关键词: Retina;    Phosphorylated tau;    Alzheimer’s disease;    P301S mouse;    Synapsis;   

DOI  :  10.1186/s40478-022-01489-3

 received in 2022-10-13, accepted in 2022-12-04,  发布年份 2022

来源: Springer

【 摘 要 】

Tauopathies, including Alzheimer’s disease, are characterized by retinal ganglion cell loss associated with amyloid and phosphorylated tau deposits. We investigated the functional impact of these histopathological alterations in the murine P301S model of tauopathy. Visual impairments were demonstrated by a decrease in visual acuity already detectable at 6 months, the onset of disease. Visual signals to the cortex and retina were delayed at 6 and 9 months, respectively. Surprisingly, the retinal output signal was delayed at the light onset and advanced at the light offset. This antagonistic effect, due to a dysfunction of the cone photoreceptor synapse, was associated with changes in the expression of the vesicular glutamate transporter and a microglial reaction. This dysfunction of retinal glutamatergic synapses suggests a novel interpretation for visual deficits in tauopathies and it highlights the potential value of the retina for the diagnostic assessment and the evaluation of therapies in Alzheimer’s disease and other tauopathies.

【 授权许可】

CC BY   
© The Author(s) 2023

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